Evidence map›Paper›PMID 39865127›Full record

ArticleScientific reports2025

Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults.

Mehdi Mollahosseini, Zeinab Yazdanpanah, Azadeh Nadjarzadeh, Masoud Mirzaei, Seyed Mehdi Kalantar, Hamid Reza Ashrafzadeh, Khadijeh Mirzaei, Hassan Mozaffari-Khosravi

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

  1. Review
  2. Life (Basel, Switzerland) · 2025
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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Mehdi MollahosseiniMolecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran.
Zeinab YazdanpanahNutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Azadeh NadjarzadehNutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Masoud MirzaeiYazd Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyed Mehdi KalantarDepartment of Medical Genetics, Shahid Sadoughi University of Medical Science, Yazd, Iran.
Hamid Reza AshrafzadehAbortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Khadijeh MirzaeiDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Hassan Mozaffari-KhosraviNutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mozaffari.kh@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the interactions between the Dietary approaches to stop hypertension (DASH) and the rs1501299 and rs6450176 SNPs in terms of cardiometabolic risk factors. This cross-sectional study was conducted on 387 adults (20-70 years old) residing in Yazd, Iran. The participants were selected from participants in the recruitment phase of the Yazd Health Study (YaHS) which is a population-based cohort of 9,962 adults. The genotypes of rs1501299 and rs6450176 SNPs were determined using the restriction fragment length polymorphism (RFLP) method. Unlike for the G allele carriers of rs1501299, high adherence to the DASH dietary pattern was related to the lower diastolic blood pressure (DBP; P-interaction = 0.014) and systolic blood pressure (SBP; P-interaction = 0.051) in the participants with TT genotype. Moreover, in individuals with the AA genotype of rs6450176 SNP, adherence to this diet was associated with lower SBP (P-interaction = 0.012), waist-to-hip ratio (WHR; P-interaction = 0.026) and waist-to-height ratio (WHtR; P-interaction = 0.040), while in G allele carriers, the mean of these items was greater in individuals with high adherence to the DASH diet. The results suggest that following the DASH diet may be related to lower blood pressure and central obesity indices only in individuals with TT genotype of rs1501299 and AA genotype of rs6450176, respectively, whereas it can be associated with higher WHR and WHtR in G allele carriers of rs6450176.

Indexed as

AdiponectinBlood PressureDietary Approaches To Stop HypertensionObesity, AbdominalPolymorphism, Single NucleotideAdultAgedAllelesCross-Sectional StudiesFemaleGenotypeHumansHypertensionIranMaleMiddle AgedAdiponectinADIPOQ protein, humanAdiponectinADIPOQARL15Blood pressureCardiovascular diseasesDietGene–environment interactionGenetic variationHypertensionNutrigenomicsObesityPolymorphism

Identifiers

PMID39865127
PMCPMC11770118

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