ArticleAnnals of vascular surgery2025
Association of Chronic Limb Ischemia Rutherford Classification with Clinical Outcomes Following Lower Extremity Revascularization.
Article in Annals of vascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The fate of the contralateral limb after major lower limb amputation for peripheral arterial disease or diabetes mellitus.BJS open · 2026Article
- Comprehensive evaluation of combined AngioJet and drug-coated balloon therapy for diabetic foot ulcers with lower extremity arterial occlusive disease.American journal of translational research · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe Rutherford Classification for chronic limb-threatening ischemia (CLTI) is used to categorize peripheral artery disease severity through history and physical examination. This study investigated whether higher Rutherford Classification correlates with worse clinical outcomes and could serve as a predictive tool.
methodsIn this prospective single-center study, 252 patients undergoing lower extremity revascularization were followed for 3 years (2020-2023). Rutherford classification was determined at presentation. Outcomes included reintervention for stenosis/occlusion, amputation rates, and mortality. Statistical analysis used chi-squared tests for categorical data and one-way ANOVA for continuous data.
resultsHigher Rutherford classifications (3-6) showed increased reoperation rates versus lower classifications (28.2% vs. 10.3%, P = 0.043), with the largest increase between classes 2 and 3 (4.7-26.8%). Amputation rates were significantly higher in classifications 4-6 vs. 0-3 (31.9% vs. 7.2%, P < 0.001), particularly between classes 4 and 5 (19.0-37.6%). Mortality rates were also higher in classes 4-6 vs. 0-3 (22.6% vs. 7.2%, P < 0.001). Rutherford Classification effectively predicts major adverse outcomes, with marked increases at specific classification transitions suggesting critical thresholds for risk stratification. Early intervention may be warranted in higher classifications. These findings support its use as a valuable prognostic tool in preoperative planning and patient counseling.
conclusionThis study validates Rutherford Classification as an effective tool for predicting adverse outcomes in CLTI patients. The clear correlation between higher classifications and increased complications supports its use in clinical decision-making, risk stratification, and determining optimal timing for surgical intervention.
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