Evidence map›Paper›PMID 39864457›Full record

ArticlePediatrics2025

Prescription Stimulant Dispensing to US Children: 2017-2023.

Sijia He, Sean Esteban McCabe, Rena M Conti, Anna Volerman, Kao-Ping Chua

Abstract read
In one paragraph

Article in Pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  7. Trends in Parent-Reported ADHD Diagnosis and Treatment Among U.S. Children, 2016-2023.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sijia HeSusan B. Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan.
Sean Esteban McCabeCenter for the Study of Drugs, Alcohol, Smoking and Health, School of Nursing, University of Michigan, Ann Arbor, Michigan.
Rena M ContiDepartment of Markets, Public Policy, and Law, Questrom School of Business, Boston University, Boston, Massachusetts.
Anna VolermanDepartments of Medicine and Pediatrics, University of Chicago, Chicago, Illinois.
Kao-Ping ChuaSusan B. Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan.

Funding

Trajectories of Prescription Nonmedical Drug MisuseR01DA031160 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEAN ESTEBAN MCCABE · 2011 to 2026
$3.7M
Insurance-related barriers to medications for opioid use disorder in private and Medicaid plansR01DA056438 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHUA, KAO-PING, NGUYEN, THUY DIEU · 2022 to 2025
$2.5M
Evaluating Policy Interventions to Decrease Excessive and Risky Perioperative Opioid PrescribingR01DA057284 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHUA, KAO-PING, WALJEE, JENNIFER FILIP · 2022 to 2025
$2.5M
NIDA NIH HHS R01 DA031160NIDA NIH HHS R01 DA056438NIDA NIH HHS R01 DA057284
6 · The paper itself

Abstract

objectiveTo evaluate changes in prescription stimulant dispensing to children aged 5 to 17 years associated with the COVID-19 pandemic and the shortage of immediate-release mixed amphetamine salts (Adderall), which was announced in October 2022.

methodsWe analyzed the 2017 to 2023 IQVIA Longitudinal Prescription Database, which captures 92% of US prescriptions. Using an interrupted time series design, we evaluated level and slope changes in the monthly stimulant-dispensing rate (number of children with stimulant dispensing per 100 000 children) in March 2020 and October 2022.

resultsIn March 2020, the monthly stimulant-dispensing rate to children declined -454.9 children per 100 000 (95% CI, -572.6 to -337.2), an 18.8% decrease relative to January 2017. After March 2020, this rate increased to 12.7 children per 100 000 per month (95% CI, 6.6-18.8). In October 2022, there was no level change (-39.7 children per 100 000; 95% CI, -189.9 to 110.5) or slope change (-12.1 children per 100 000 per month; 95% CI, -27.5 to 3.3), although estimates were negative. During October 2022, there was a level decrease in the monthly dispensing rate for immediate-release mixed amphetamine salts and a level increase in the monthly dispensing rate for dexmethylphenidate.

conclusionsStimulant dispensing to children declined after the pandemic began. Dispensing may also have declined after October 2022, but estimates were not significant, partly because decreased dispensing of immediate-release mixed amphetamine salts was offset by increased dispensing of other stimulants. Findings suggest the shortage may have prompted children to switch to alternative stimulants. Future research should evaluate whether any switches led to adverse events.

Indexed as

AmphetaminesAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsCOVID-19Drug PrescriptionsPractice Patterns, Physicians'AdolescentChildChild, PreschoolHumansInterrupted Time Series AnalysisUnited StatesAdderallAmphetaminesCentral Nervous System Stimulants

Identifiers

PMID39864457
PMCPMC12811066

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.