Evidence map›Paper›PMID 39864418›Full record

ArticleInternational archives of allergy and immunology2025

Adipose Tissue-Derived Mesenchymal Stem Cells Regulate Th17/Treg Cells in a Rat Model of Allergic Rhinitis by Activating IL-2/JAK-3/STAT-5 Signaling Pathway.

Yun Hou, Fei Fei Li, Jiang Wei Kong, Youhu Wang, Yunyan Pan, Hao Ding, Xu Dong Wei

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In one paragraph

Article in International archives of allergy and immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yun HouDepartment of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Lanzhou University, The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Fei Fei LiThe Second Clinical Medical College, Lanzhou University, Lanzhou University Second Hospital, Lanzhou, China.
Jiang Wei KongDepartment of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Lanzhou University, The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Youhu WangDepartment of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Lanzhou University, The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Yunyan PanThe Second Clinical Medical College, Lanzhou University, Lanzhou University Second Hospital, Lanzhou, China.
Hao DingThe Second Clinical Medical College, Lanzhou University, Lanzhou University Second Hospital, Lanzhou, China.
Xu Dong WeiDepartment of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Lanzhou University, The First School of Clinical Medicine, Lanzhou University, Lanzhou, China, weixd93@lzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of the study was to investigate how adipose-derived mesenchymal stem cells regulate the balance between regulatory T (Treg) cells and Th17 cells through the IL-2/JAK-3/STAT-5 signaling pathway in a rat model of allergic rhinitis (AR).

methodsAdipose-derived stem cells (ADSCs) were used to treat an ovalbumin (OVA)-induced AR rat model. The pathological changes and nasal symptoms were observed by HE staining and scanning electron microscopy. The concentrations of OVA-sIgE, IL-10, and IL-17 in serum were measured by enzyme-linked immunosorbent assay (ELISA). The mRNA expressions of JAK-3, STAT-5, forkhead box P3 (Foxp3), and retinoic acid-associated orphan receptor γt (RORγt) in nasal mucosa were detected by reverse transcription-polymerase chain reaction (RT-PCR). The expression of IL-2, JAK-3, and STAT-5 proteins in nasal mucosa was detected by Western blotting, and the expression patterns of these proteins were analyzed.

resultsADSCs significantly reduced nasal symptoms and histological abnormalities by significantly reducing the levels of OVA-sIgE, IL-17 and increasing IL-10 levels. The expressions of IL-2, JAK-3, STAT-5, Foxp3, and RORγt in the nasal mucosa of AR rats were abnormal, but ADSCs treatment significantly restored this change.

conclusionADSC can control the development of Treg/Th17 cells by the IL-2/JAK-3/STAT-5 signaling pathway and reduce OVA-induced allergic inflammation.

Indexed as

Adipose TissueInterleukin-2Mesenchymal Stem CellsRhinitis, AllergicTh17 CellsT-Lymphocytes, RegulatoryAnimalsDisease Models, AnimalJanus Kinase 3MaleMesenchymal Stem Cell TransplantationNasal MucosaOvalbuminRatsRats, Sprague-DawleySignal TransductionInterleukin-2Janus Kinase 3OvalbuminSTAT5 Transcription FactorAdipose tissue-derived stem cellsAllergic rhinitisInterleukin-2Regulatory T cellsT helper 17 cells

Identifiers

PMID39864418
PMCPMC12965727

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.