Evidence map›Paper›PMID 39863844›Full record

ArticleBMC cancer2025

Clinical implications of DNA ploidy, stroma, and nucleotyping in predicting peritoneal metastasis risk for gastric cancer.

Jingwen Yuan, Yue Jiang, Fangfang Chen, Tian Li, Zhi Zeng, Shasha Ruan, Junfeng Yan, Jiatong Lu, Qiang Li, Jingping Yuan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jingwen Yuan *Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Yue Jiang *Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Fangfang Chen *Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Tian LiTianjin Key Laboratory of Acute Abdomen Disease-Associated Organ Injury and ITCWM Repair, Institute of Integrative Medicine of Acute Abdominal Diseases, Tianjin, 300100, China.
Zhi ZengDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Shasha RuanDepartment of Clinical Oncology, Renmin Hospital of Wuhan University, The First Clinical College of Wuhan University, Wuhan, 430060, Hubei, China.
Junfeng YanDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Jiatong LuDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Qiang LiDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Jingping YuanDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. yuanjingping@whu.edu.cn.
Qiang TongDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, 430060, China. qiangtong@whu.edu.cn.

Funding

Guidance Foundation of Renmin Hospital of Wuhan University RMYD2018M67National Natural Science Foundation of China 81172186Natural Science Foundation of Hubei Province 2018CFB504
6 · The paper itself

Abstract

backgroundGastric cancer peritoneal metastasis lacks effective predictive indices. This article retrospectively explored predictive values of DNA ploidy, stroma, and nucleotyping in gastric cancer peritoneal metastasis.

methodsA comprehensive analysis was conducted on specimens obtained from 80 gastric cancer patients who underwent gastric resection at the Department of Gastrointestinal Surgery of Wuhan University Renmin Hospital. Tumor tissues were sectioned and stained. DNA ploidy, stroma, and nucleotyping were quantified using microscopy and digital analysis software. Data analysis was employed by Pearson Chi-square, continuous correction Chi-square, and binary logistic regression.

resultsUsing both univariate and multivariate analysis, pathological T stage and nucleotyping exhibited a positive correlation with peritoneal metastasis. DNA ploidy and stroma showed a positive correlation in univariate analysis. Chi-square tests demonstrated a positive correlation of DNA ploidy, stroma, and nucleotyping with peritoneal metastasis. The combined application of these three indicators displayed heightened predictive value for peritoneal metastasis. Non-diploid status, high stroma, and chromosomal heterogeneity emerged as positive factors for peritoneal metastasis in gastric cancer.

conclusionsDNA ploidy, stroma, and nucleotyping prove to be predictive factors for peritoneal metastasis, with enhanced predictive efficacy when combined in pairs.

Indexed as

Peritoneal NeoplasmsPloidiesStomach NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesStromal CellsDNA ploidyGastric cancerNucleotypingPeritoneal metastasisPredictionStroma

Identifiers

PMID39863844
PMCPMC11762900

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