Evidence map›Paper›PMID 39863793›Full record

ArticleScientific reports2025

Inaudible airborne ultrasound affects emotional states in the olfactory bulbectomized rat depression model.

Tsugumi Yamauchi, Kou Takahashi, Toshinori Yoshioka, Daisuke Yamada, Yoshio Nakano, Satoka Kasai, Satoshi Iriyama, Kazumi Yoshizawa, Shoichi Nishino, Satoru Miyazaki and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tsugumi Yamauchi *Laboratory of Pharmacology, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Kou Takahashi *Department of Neurobiology and Anatomy, Kochi Medical School, Kochi University, Kochi, Japan.
Toshinori YoshiokaLaboratory of Pharmacology, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Daisuke YamadaLaboratory of Pharmacology, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Yoshio NakanoLaboratory of Bioinformatics, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Satoka KasaiLaboratory of Pharmacology and Therapeutics, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Satoshi IriyamaLaboratory of Quantum information dynamics, Department of Information Sciences, Faculty of Science and Technology, Tokyo University of Science, Chiba, Japan.
Kazumi YoshizawaLaboratory of Pharmacology and Therapeutics, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Shoichi NishinoFUJIMIC, Inc., Tokyo, Japan.
Satoru MiyazakiLaboratory of Bioinformatics, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Akiyoshi SaitohLaboratory of Pharmacology, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan. akiyoshi_saitoh@rs.tus.ac.jp.

Funding

Grant-in-Aid for JSPS Fellows JP23KJ1972
6 · The paper itself

Abstract

Recently, exposure to sounds with ultrasound (US) components has been shown to modulate brain activity. However, the effects of US on emotional states remain poorly understood. We previously demonstrated that the olfactory bulbectomized (OBX) rat depression model is suitable for examining the effects of audible sounds on emotionality. Here, we investigated the impact of US exposure on the emotional state of OBX rats. In naive rats, exposure to 100 kHz US for 1 h did not increase the number of c-Fos-positive cells in auditory-related cortical areas, and US, as a tone cue, did not elicit a conditioned fear response in the auditory fear conditioning test. These results indicate that the frequency of 100 kHz is hard to hear for rats. However, US improved hyperemotionality (HE) scores and decreased plasma corticosterone levels in OBX rats, suggesting ameliorative effects on depression-like symptoms and stress. In contrast to HE scores, US exposure did not influence anxiety-like behaviors in the elevated plus maze. In conclusion, we demonstrated that exposure to airborne US can alleviate depressive-like symptoms in the OBX rat depression model. This is the first study to show that exposure to airborne US alone produces changes in emotional states in an animal model.

Indexed as

DepressionEmotionsOlfactory BulbAnimalsAnxietyBehavior, AnimalCorticosteroneDisease Models, AnimalFearMaleProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleyCorticosteroneProto-Oncogene Proteins c-fosAntidepressant therapyAnxietyDepressionOlfactory bulbectomized ratsUltrasound

Identifiers

PMID39863793
PMCPMC11762311

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.