Evidence map›Paper›PMID 39863776›Full record

ArticleInternational journal of obesity (2005)2025

Cachectic biomarkers as confounders behind the obesity paradox in patients with acute decompensated heart failure.

Yusuke Miura, Satoshi Higuchi, Takashi Kohno, Yasuyuki Shiraishi, Mitsunobu Kitamura, Yuji Nagatomo, Yumiko Kawakubo Ichihara, Atsushi Mizuno, Shintaro Nakano, Kyoko Soejima and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yusuke Miura *Department of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5719-2213
Satoshi Higuchi *Division of Cardiology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan. sahiguchi-circ@umin.ac.jp.ORCID http://orcid.org/0000-0002-7914-8256
Takashi KohnoDepartment of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan. kohno-ta@ks.kyorin-u.ac.jp.
Yasuyuki ShiraishiDepartment of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Mitsunobu KitamuraDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
Yuji NagatomoDepartment of Cardiology, National Defense Medical College, Saitama, Japan.
Yumiko Kawakubo IchiharaDepartment of Cardiology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Atsushi MizunoDepartment of Cardiology, St Luke's International Hospital, Tokyo, Japan.
Shintaro NakanoDepartment of Cardiology, Saitama Medical University, International Medical Center, Saitama, Japan.
Kyoko SoejimaDepartment of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan.
Ayumi GodaDepartment of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan.
Shun KohsakaDepartment of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Tsutomu YoshikawaDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
West Tokyo Heart Failure (WET-HF) Registry Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is a risk factor for heart failure (HF) development but is associated with a lower incidence of mortality in HF patients. This obesity paradox may be confounded by unrecognized comorbidities, including cachexia.

methodsA retrospective assessment was conducted using data from a prospectively recruiting multicenter registry, which included consecutive acute heart failure patients. A low, normal, and high body mass index (BMI) was defined as <20 kg/m

resultsThis study evaluated 3314 patients (mean BMI, 22 ± 4 kg/m

conclusionsBMI could be only a surrogate marker. The cachectic biomarkers may reflect the underlying conditions and contribute to elucidating the obesity paradox.

Indexed as

CachexiaHeart FailureObesityObesity ParadoxAcute DiseaseAgedBiomarkersBody Mass IndexFemaleHumansMaleMiddle AgedProspective StudiesRegistriesRetrospective StudiesBiomarkers

Identifiers

PMID39863776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.