Evidence map›Paper›PMID 39863729›Full record

ArticleMikrochimica acta2025

Electrochemical aptasensor for the selective detection of vancomycin based on nanostructured "in-lab" printed electrodes.

Malek Bibani, Magdolna Casian, Bogdan Feier, Diana Bogdan, Oana Hosu-Stancioiu, Nadia Ktari, Rafik Kalfat, Cecilia Cristea

Abstract read
In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Malek Bibani *Department of Analytical Chemistry, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 4 Pasteur Street, 400349, Cluj-Napoca, Romania.ORCID 0000-0002-0950-0875
Magdolna Casian *Department of Analytical Chemistry, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 4 Pasteur Street, 400349, Cluj-Napoca, Romania.ORCID 0000-0002-0070-4142
Bogdan FeierDepartment of Analytical Chemistry, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 4 Pasteur Street, 400349, Cluj-Napoca, Romania. feier.george@umfcluj.ro.ORCID 0000-0002-9309-0951
Diana BogdanNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat St., 400293, Cluj-Napoca, Romania.ORCID 0000-0002-5046-4837
Oana Hosu-StancioiuDepartment of Analytical Chemistry, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 4 Pasteur Street, 400349, Cluj-Napoca, Romania.ORCID 0000-0002-3579-5195
Nadia KtariLaboratoire Matériaux, Traitement Et Analyse, INRAP, BiotechPole Sidi-Thabet, 2020, Ariana, Tunisia.ORCID 0000-0001-9823-9818
Rafik KalfatLaboratoire Matériaux, Traitement Et Analyse, INRAP, BiotechPole Sidi-Thabet, 2020, Ariana, Tunisia.ORCID 0000-0001-6638-9133
Cecilia CristeaDepartment of Analytical Chemistry, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 4 Pasteur Street, 400349, Cluj-Napoca, Romania.ORCID 0000-0002-4158-3324

Funding

Agence Universitaire de la Francophonie postdoctoral fellowship Eugen Ionescu" programEuropean Union's Horizon Europe research and innovation program under the grant agreement "European integration of new technologies and social-economic solutions for increasing consumer trust and engagement in seafood products" (FishEuTrust) Grant Agreement: 101060712/2022Ministry of Research, Innovation and Digitization, CNCS/CCCDI-UEFISCDI project number N-IV-P8-8.1-PRE-HE-ORG-2023-0076, within PNCDI IVUMF internal grant 648/1/11.01.2024
6 · The paper itself

Abstract

A label-free, flexible, and disposable aptasensor was designed for the rapid on-site detection of vancomycin (VAN) levels. The electrochemical sensor was based on lab-printed carbon electrodes (C-PE) enriched with cauliflower-shaped gold nanostructures (AuNSs), on which VAN-specific aptamers were immobilized as biorecognition elements and short-chain thiols as blocking agents. The AuNSs, characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM), enhanced the electrochemical properties of the platform and the aptamer immobilization active sites. The developed disposable aptasensor allowed label-free detection of VAN via electrochemical impedance spectroscopy (EIS) across a wide range of concentrations (50-1000 nM), with a limit of detection (LOD) of 1.721 nM. The aptasensor presented good selectivity against some commonly found interferences in human serum and milk and was successfully applied to the analysis of these samples.

Indexed as

Anti-Bacterial AgentsAptamers, NucleotideBiosensing TechniquesElectrochemical TechniquesNanostructuresVancomycinAnimalsCarbonElectrodesGoldHumansLimit of DetectionMetal NanoparticlesMilkAnti-Bacterial AgentsAptamers, NucleotideCarbonGoldVancomycinAntibiotic resistanceCauliflower-shaped gold nanostructuresEISElectrochemical aptasensorGold nanostructureVancomycin detection

Identifiers

PMID39863729
PMCPMC11762413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.