Evidence map›Paper›PMID 39863686›Full record

Trial reportScientific reports2025

Randomized controlled trial on the efficacy of forest walking compared to urban walking in enhancing mucosal immunity.

Hiroko Ochiai, Shigeru Inoue, Gaku Masuda, Shiho Amagasa, Tomohiko Sugishita, Toshiya Ochiai, Naoko Yanagisawa, Yoshio Nakata, Michiko Imai

Abstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Forest Bathing (Medical sciences (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hiroko OchiaiLaboratory of Regenerative Medicine, Division of Hearing and Balance Disorder, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, 152-8902, Japan. ochiroko@gmail.com.
Shigeru InoueDepartment of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, 160- 8402, Japan.
Gaku MasudaThe Section of Global Health, Department of Hygiene and Public Health, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.
Shiho AmagasaDepartment of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, 160- 8402, Japan.
Tomohiko SugishitaThe Section of Global Health, Department of Hygiene and Public Health, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.
Toshiya OchiaiForest Baubiologie Studio Inc., Tokyo, 192-0912, Japan.
Naoko YanagisawaDepartment of Microbiology and Immunology, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.
Yoshio NakataInstitute of Health and Sport Sciences, University of Tsukuba, Tsukuba, 305-8574, Japan.
Michiko ImaiLe Verseau Inc., Tokyo, 156-0051, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scientific research on forest therapy's preventive medical and mental health effects has advanced, but the need for clear evidence for practical applications remains. We conducted an unblinded randomized controlled trial involving healthy men aged 40-70 to compare the physiological and psychological effects of forest and urban walking. Eighty-four participants were randomly assigned to either the forest or urban group, with 78 completing 90-min walks and analysis. The primary outcome measured was the change in saliva-secreted immunoglobulin A (sIgA) levels. Evaluating researchers were blinded to the groups, but participants and on-site staff were not. Here, we demonstrate a significant increase in saliva-secreted immunoglobulin A (sIgA) levels in the forest group. Furthermore, forest walking resulted in improved mood, including a reduction in stress hormone levels. In conclusion, mindful forest walking has the potential to enhance immunity and promote health. Clinical trial registration: University Hospital Medical Information Network. Trail registration number: UMIN000045851. Approval date: 25/10/2021.

Indexed as

ForestsImmunity, MucosalWalkingAdultAgedHumansImmunoglobulin AMaleMiddle AgedSalivaImmunoglobulin AForest therapyForest walkingMental healthMucosal immunityRandomized controlled trialSaliva-secreted immunoglobulin A

Identifiers

PMID39863686
PMCPMC11762291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.