Evidence map›Paper›PMID 39863653›Full record

ArticleScientific reports2025

Characteristics of transition to turbulence in a healthy thoracic aorta using large eddy simulation.

Kuiyu Cheng, Shehnaz Akhtar, Kwan Yong Lee, Sang-Wook Lee

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Ischemic stroke due to non-atherosclerotic aortic mural thrombus associated with iron deficiency anemia successfully treated with surgery.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Kuiyu ChengSchool of Mechanical Engineering, University of Ulsan, Ulsan, 44610, Republic of Korea.
Shehnaz AkhtarSchool of Mechanical Engineering, University of Ulsan, Ulsan, 44610, Republic of Korea.
Kwan Yong LeeCardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, Seoul, Republic of Korea.
Sang-Wook LeeSchool of Mechanical Engineering, University of Ulsan, Ulsan, 44610, Republic of Korea. leesw@ulsan.ac.kr.

Funding

The National Research Foundation of Korea (NRF) 2020R1I1A3066617
6 · The paper itself

Abstract

This study employed large eddy simulation (LES) with the wall-adapting local eddy-viscosity (WALE) model to investigate transitional flow characteristics in an idealized model of a healthy thoracic aorta. The OpenFOAM solver pimpleFoam was used to simulate blood flow as an incompressible Newtonian fluid, with the aortic walls treated as rigid boundaries. Simulations were conducted for 30 cardiac cycles and ensemble averaging was employed to ensure statistically reliable results. Main hemodynamic parameters, such as velocity fields, turbulence intensity turbulent kinetic energy (TKE), oscillatory shear index (OSI) and wall shear stress (WSS), were analyzed throughout the circulatory system. Through 3D computational fluid dynamics (CFD) visualization, we explained the transition from laminar to turbulent flow and its development throughout the cardiac cycle. The results demonstrated that turbulence originates in the aortic arch following the peak systole phase and further develops in the aortic arch and descending aorta during the mid-deceleration and end-systole phases, with the maximum turbulence intensity exceeding 25%. WSS reached up to 30 Pa during the peak systole, with an average WSS of 6.5 Pa across the cardiac cycle. Low and oscillatory WSS were observed during diastole which can potentially contribute to the development of vascular diseases including, aortic dissection and atherosclerosis.

Indexed as

Aorta, ThoracicModels, CardiovascularBlood Flow VelocityComputer SimulationHemodynamicsHumansHydrodynamicsStress, MechanicalHealthy thoracic aortaLaminar-turbulent transitionLarge eddy simulationOpenFOAMTurbulent kinetic energyWall shear stress

Identifiers

PMID39863653
PMCPMC11762701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.