Evidence map›Paper›PMID 39863648›Full record

ArticleScientific reports2025

Berberine decorated zinc oxide loaded chitosan nanoparticles a potent anti cancer agent against breast cancer.

Fatemeh Esnaashari, Hojjatolah Zamani, Hossein Zahmatkesh, Mojtaba Soleimani, Golnesa Amirian Dashtaki, Behnam Rasti

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Fatemeh EsnaashariDepartment of Biology, Lahijan Branch, Islamic Azad University, Lahijan, Iran.
Hojjatolah ZamaniDepartment of Biology, University of Guilan, Rasht, Iran. h_zamani@guilan.ac.ir.
Hossein ZahmatkeshDepartment of Biology, University of Guilan, Rasht, Iran. hza.zahmatkesh@gmail.com.
Mojtaba SoleimaniDepartment of Chemistry, Lahijan Branch, Islamic Azad University, Lahijan, Iran.
Golnesa Amirian DashtakiDepartment of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Behnam RastiDepartment of Microbiology, Faculty of Basic Sciences, Lahijan Branch, Islamic Azad University, Lahijan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer ranks as the second leading reason of cancer mortality among females globally, emphasizing the critical need for novel anticancer treatments. In current work, berberine-zinc oxide conjugated chitosan nanoparticles were synthesized and characterized using various characterization techniques. The cytotoxic effects of CS-ZnO-Ber NPs on MCF-7 cells were assessed using the MTT assay. Also, annexin V-FITC/PI double staining, Hoechst 33,342 staining, caspases-8 and 9 activity assays, and cell cycle analysis were performed. Furthermore, the mRNA levels of Bax and Bcl-2 genes were quantified using qPCR. Additionally, cell migration was evaluated using a scratch assay. The IC

Indexed as

Antineoplastic AgentsBerberineBreast NeoplasmsChitosanNanoparticlesZinc OxideApoptosisCell MovementFemaleHumansMCF-7 CellsAntineoplastic AgentsBerberineChitosanZinc OxideApoptosisBerberineBreast cancerFlow cytometry

Identifiers

PMID39863648
PMCPMC11762321

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.