ArticleScientific reports2025
Ultra high density imaging arrays in diffuse optical tomography for human brain mapping improve image quality and decoding performance.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Optical performance of minimally invasive brain implants: a simulation and phantom study.Biomedical optics express · 2026Article
- Disrupted functional connectivity during stroke recovery revealed via bedside optical neuroimaging.Neurophotonics · 2026Article
- Extending effective multiplicity for independent designs in multichannel fNIRS studies.Neurophotonics · 2026Article
- Advances in fully integrated wearable near-infrared spectroscopy: hardware innovations and biomedical applications.JPhys photonics · 2026Review
- Surface-based image reconstruction optimization for high-density functional near-infrared spectroscopy.Neurophotonics · 2026Article
- Visual Semantic Encoding and Identification of Naturalistic Movies via High-Density Diffuse Optical Tomography.bioRxiv : the preprint server for biology · 2025Article
- A cost-effective diffuse optical tomographic system for imaging absorbing and fluorescent targets in a scattering medium.Scientific reports · 2025Article
- Mapping human cerebral blood flow with high-density, multi-channel speckle contrast optical spectroscopy.Communications biology · 2025Article
- Synthetic-data-driven LSTM framework for tracing cardiac pulsation in optical signals.Biomedical optics express · 2025Article
- Evaluation of layered tissue scattering properties: a time-domain spatially resolved spectroscopy approach.Journal of biomedical optics · 2025Article
- Mapping brain function underlying naturalistic motor observation and imitation using high-density diffuse optical tomography.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional brain mapping using whole-head very high-density diffuse optical tomography.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Measurement prediction and power analysis for fNIRS and DOT.Imaging neuroscience (Cambridge, Mass.)Article
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Abstract
Functional magnetic resonance imaging (fMRI) has dramatically advanced non-invasive human brain mapping and decoding. Functional near-infrared spectroscopy (fNIRS) and high-density diffuse optical tomography (HD-DOT) non-invasively measure blood oxygen fluctuations related to brain activity, like fMRI, at the brain surface, using more-lightweight equipment that circumvents ergonomic and logistical limitations of fMRI. HD-DOT grids have smaller inter-optode spacing (~ 13 mm) than sparse fNIRS (~ 30 mm) and therefore provide higher image quality, with spatial resolution ~ 1/2 that of fMRI, when using the several source-detector distances (13-40 mm) afforded by the HD-DOT grid. Herein, simulations indicated reducing inter-optode spacing to 6.5 mm, creating a higher-density grid with more source-detector distances, would further improve image quality and noise-resolution tradeoff, with diminishing returns below 6.5 mm. We then constructed an ultra-high-density DOT system (6.5-mm spacing) with 140 dB dynamic range that imaged stimulus-evoked activations with 30-50% higher spatial resolution and repeatable multi-focal activity with excellent agreement with participant-matched fMRI. Further, this system decoded visual stimulus position with 19-35% lower error than previous HD-DOT, throughout occipital cortex.
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