ArticleScientific reports2025
The diagnostic value of cytology in the mammary intraductal lesions of patients with pathological nipple discharge.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nipple aspirate fluid as a proximal breast liquid biopsy platform: advancing precision risk management in breast cancer.Clinical proteomics · 2026Review
- Congenital unilateral athelia associated with mammary Paget's disease, high-grade ductal carcinomaFrontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to explore the diagnostic value of the two cytology techniques, including liquid-based cytology of mammary ductal lavage fluid and nipple discharge smear cytology, in the intraductal lesions in patients with pathological nipple discharge (PND). This retrospective analysis included 119 patients with PND who underwent surgical treatment. At the same time, they all underwent fiberoptic ductoscopy (FDS), nipple discharge smear cytology and liquid-based cytology of ductal lavage fluid before surgery. With postoperative pathological diagnosis as the gold standard, we compared the clinical diagnostic efficacy of the two cytology techniques applied independently and combined with FDS to evaluate their diagnostic value in intraductal lesions. Finally, the receiver operating characteristic (ROC) curves and the area under the curve (AUC) were used to evaluate the diagnostic value of each examination method. There were 22 breast malignant tumors, 75 intraductal papillomas and 22 non-tumorous lesions among the 119 PND patients. The cell types of liquid-based cytology of ductal lavage fluid was significantly more abundant than that of smear cytology, and the detection rate of tumor cells, atypia cells and atypical hyperplasia cells was significantly increased. The diagnostic accuracy and sensitivity of liquid-based cytology of ductal lavage fluid were significantly higher than that of smear cytology (P < 0.05). At the same time, the accuracy of liquid-based cytology was superior to that of smear cytology when combined with FDS (P < 0.05), and the diagnostic efficiency was excellent. FDS combined with liquid-based cytology of ductal lavage fluid was more effective than the other methods (AUC = 0.8182). When diagnosing the intraductal space-occupying lesions in PND patients, liquid-based cytology of ductal lavage fluid can obtain more abundant intraductal shed cells. This advantage can compensate for the limitation of FDS for diagnosing terminal ductal unit lesions and significantly improve the early diagnosis rate of intraductal lesions, especially intraductal malignant tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.