Evidence map›Paper›PMID 39863305›Full record

ArticleLupus science & medicine2025

Metabolic profiles of cutaneous lupus have abnormalities in the nicotinamide adenine dinucleotide pathway.

Laila F Abbas, Grant Barber, Grace Lu, Bahir Chamseddin, Hieu Vu, Ling Cai, Divya Srivastava, Rajiv L Nijhawan, Richard C Wang, Benjamin F Chong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus science & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laila F AbbasDermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Grant BarberDermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Grace LuDermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Bahir ChamseddinDermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Hieu VuChildren's Medical Center Research Institute, University of Texas Southwestern, Dallas, Texas, USA.
Ling CaiChildren's Medical Center Research Institute, University of Texas Southwestern, Dallas, Texas, USA.
Divya SrivastavaDermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Rajiv L NijhawanDermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Richard C WangDermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Benjamin F ChongDermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA Ben.Chong@UTSouthwestern.edu.ORCID 0000-0002-4092-7658

Funding

Mechanisms of Glucose Dependence in Proliferating CellsR01AR072655 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI WANG, RICHARD C · 2018 to 2022
$1.7M
Molecular Markers in Discoid Lupus ErythematousK23AR061441 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI CHONG, BENJAMIN FRANKLIN · 2012 to 2016
$653k
NIAMS NIH HHS K23 AR061441NIAMS NIH HHS R01 AR072655
6 · The paper itself

Abstract

objectiveMetabolic reprogramming plays a critical role in modulating the innate and adaptive immune response, but its role in cutaneous autoimmune diseases, such as cutaneous lupus erythematosus (CLE), is less well studied. An improved understanding of the metabolic pathways dysregulated in CLE may lead to novel treatment options, biomarkers and insights into disease pathogenesis. The objective was to compare metabolomic profiles in the skin and sera of CLE and control patients using liquid chromatography-mass spectrometry (LC-MS).

methodsThis was a cross-sectional pilot study comparing metabolomic sera and skin profiles of patients with CLE and normal controls. Patients were recruited from outpatient dermatology clinics at the University of Texas Southwestern and Parkland Health in Dallas, Texas, from January 2019 to October 2020. Skin and serum samples underwent LC-MS analysis. Disease sample metabolite levels were compared with controls, with significance levels adjusted for multiple hypothesis testing.

results17 serum samples (9 CLE, 8 control) and 11 skin samples (5 CLE, 6 control) were analysed using LC-MS, yielding 313 known unique metabolic structures from CLE samples. Patients with CLE were found to have 11 metabolites of differential abundance in the skin, but only 2 in the sera. CLE skin showed increased levels of citrulline (log

conclusionsMetabolites associated with the NAD

Indexed as

Lupus Erythematosus, CutaneousMetabolomeNADSkinAdultBiomarkersCase-Control StudiesChromatography, LiquidCross-Sectional StudiesFemaleHumansMaleMass SpectrometryMetabolic Networks and PathwaysMetabolomicsMiddle AgedBiomarkersNADAutoimmune DiseasesLupus Erythematosus, SystemicTherapeutics

Identifiers

PMID39863305
PMCPMC11784198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.