Evidence map›Paper›PMID 39862330›Full record

ArticleVirchows Archiv : an international journal of pathology2025

MAPK1IP1L::TFE3-rearranged renal cell carcinoma: a novel fusion adding to the differential diagnosis of oncocytic renal neoplasms.

Anne V Cheng, Douglas J Wu, Lisa Aviva Friedman, Emily Chan, Sean R Williamson, Laurence A Galea, Ankur R Sangoi

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Anne V ChengDepartment of Pathology, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Douglas J WuDepartment of Pathology, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Lisa Aviva FriedmanDepartment of Pathology, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Emily ChanDepartment of Pathology, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Sean R WilliamsonDepartment of Pathology, Cleveland Clinic, Cleveland, OH, USA.
Laurence A GaleaDepartment of Anatomical Pathology, Sonic Healthcare, Melbourne PathologyVIC, Australia.
Ankur R SangoiDepartment of Pathology, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA, 94305, USA. asangoi@stanford.edu.ORCID http://orcid.org/0000-0003-0874-8964

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beyond the more common TFE3 fusion partners PRCC, ASPSCR1, and SFPQ, additional less common fusion partners of TFE3-rearranged renal cell carcinoma (RCC) have been described. Herein, we present an example of TFE3-rearranged renal cell carcinoma harboring fusion partner MAPK1IP1L, a rare rearrangement with only one other reported tumor found in the literature. The currently reported TFE3-rearranged RCC demonstrates unique histological features compared to the previously reported tumor including dense eosinophilic cytoplasm and nuclear pseudoinclusions (corroborated by electron microscopic evaluation), with features not typically seen in other TFE3-rearranged RCCs. Recognizing this novel fusion may be important in the identification, classification, and development of potential therapeutic agents of kidney tumors in the future.

Indexed as

Adenoma, OxyphilicBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBiomarkers, TumorCarcinoma, Renal CellKidney NeoplasmsOncogene Proteins, FusionDiagnosis, DifferentialFemaleGene FusionGene RearrangementHumansMaleMiddle AgedBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBiomarkers, TumorOncogene Proteins, FusionTFE3 protein, humanMAPK1IP1LOncocyticRenal cell carcinomaTFE3Translocation

Identifiers

PMID39862330

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.