Evidence map›Paper›PMID 39862140›Full record

ArticleFuture science OA2025

Colonic strictures in Crohn's disease: a non-surgical survival.

Sarra Laabidi, Hamed Aboubecrine, Salma Souissi, Donia Gouiaa, Asma Labidi, Nadia Ben Mustapha, Anis Haddad, Amine Sebai, Meriem Serghini, Monia Fekih and 2 more

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Article in Future science OA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sarra LaabidiGastroenterology Department, La Rabta Hospital, Tunis, Tunisia.
Hamed AboubecrineGastroenterology Department, La Rabta Hospital, Tunis, Tunisia.
Salma SouissiGastroenterology Department, La Rabta Hospital, Tunis, Tunisia.
Donia GouiaaGastroenterology Department, La Rabta Hospital, Tunis, Tunisia.
Asma LabidiGastroenterology Department, La Rabta Hospital, Tunis, Tunisia.
Nadia Ben MustaphaGastroenterology Department, La Rabta Hospital, Tunis, Tunisia.
Anis HaddadSurgery Department "A", La Rabta Hospital, Tunis, Tunisia.
Amine SebaiSurgery Department "A", La Rabta Hospital, Tunis, Tunisia.
Meriem SerghiniGastroenterology Department, La Rabta Hospital, Tunis, Tunisia.
Monia FekihGastroenterology Department, Sahloul Hospital, Sousse, Tunisia.
Hanene JaziriGastroenterology Department, Sahloul Hospital, Sousse, Tunisia.
Jalel BoubakerGastroenterology Department, La Rabta Hospital, Tunis, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColonic stenosis in Crohn's disease (CD) is uncommon, and data on surgery-free survival are limited. This study aimed to determine surgery-free survival rates and identify associated factors. PATIENTS AND

methodsA retrospective study was conducted from 2003 to 2022, including patients with CD complicated by colonic stenosis. Patients with uncertain diagnoses or follow-up periods of less than six months were excluded.

resultsFifty-six patients were included (median age 44 years [range 14-65], male-to-female ratio = 0.93). Surgery-free survival rates were 58.9% at 6 months, 43.7% at 2 years, and 31.7% at 5 years, with an average surgery-free survival of 46.7 months. Univariate analysis showed that joint manifestations (p = 0.01), corticosteroids (p = 0.02), anti-TNF alpha (p = 0.02), salicylates (p = 0.02), and azathioprine (p = 0.01) increased surgery-free survival. Complications such as collections or internal fistulas (p = 0.03), parietal ulceration on imaging (p = 0.01), and acute intestinal obstruction (p = 0.01) were associated with reduced surgery-free survival. In multivariate analysis, biologic therapy was the only independent protective factor against surgery (p = 0.001, OR = 0.19).

conclusionThe early introduction of biologic therapy is crucial for increasing surgery-free survival in patients with colonic stenosis in CD, given the limited effectiveness of conventional treatments.

Indexed as

anti TNF alpha therapycolonic strictureCrohn’s diseaseInflammatory bowel diseasemedical treatmentprognosticsurgerysurvival

Identifiers

PMID39862140
PMCPMC11776860

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