Evidence map›Paper›PMID 39861867›Full record

ArticleViruses2025

COVID-19 Vaccine Booster Dose Fails to Enhance Antibody Response to Omicron Variant in Reinfected Healthcare Workers.

Leire Fernández-Ciriza, Álvaro González, José Luis Del Pozo, Alejandro Fernandez-Montero, Francisco Carmona-Torre, Paula Martínez de Aguirre, María Del Mar Sarasa, Silvia Carlos, Gabriel Reina

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leire Fernández-CirizaDepartment of Microbiology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-1874-8338
Álvaro GonzálezDepartment of Biochemistry, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-1423-273X
José Luis Del PozoDepartment of Microbiology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-5402-3334
Alejandro Fernandez-MonteroNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.ORCID 0000-0002-8741-7401
Francisco Carmona-TorreNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.ORCID 0000-0002-8281-9583
Paula Martínez de AguirreDepartment of Microbiology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
María Del Mar SarasaDepartment of Microbiology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Silvia CarlosNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
Gabriel ReinaDepartment of Microbiology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-4079-9753

Funding

Roche Diagnostics International SAVIN Project
6 · The paper itself

Abstract

The emergence of new variants and diverse vaccination regimens have raised uncertainty about vaccine effectiveness against SARS-CoV-2. This study aims to investigate the impact of Omicron primo-/reinfection and primary vaccination schedules on the immunogenicity of an mRNA-based booster dose over a six-month period. We conducted a prospective cohort study to assess the durability and level of antibodies of 678 healthcare workers fully vaccinated against COVID-19. They were categorized based on their primary vaccination regimen. Blood samples were collected before the booster dose and 1 and 6 months after. Significant Anti-S-RBD differences were found between previously infected and naïve volunteers (

Indexed as

Antibodies, ViralAntibody FormationCOVID-19COVID-19 VaccinesHealth PersonnelImmunization, SecondaryReinfectionSARS-CoV-2AdultFemaleHumansImmunization ScheduleMaleMiddle AgedProspective StudiesSpike Glycoprotein, CoronavirusAntibodies, ViralCOVID-19 VaccinesSpike Glycoprotein, CoronavirusboosterCOVID-19immunogenicitymRNA vaccineOmicronreinfection

Identifiers

PMID39861867
PMCPMC11769551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.