Evidence map›Paper›PMID 39861850›Full record

ArticleViruses2025

Serosurvey of Bovine Viral Diarrhea Virus in Cattle in Southern Japan and Estimation of Its Transmissibility by Transient Infection in Nonvaccinated Cattle.

Norikazu Isoda, Satoshi Sekiguchi, Chika Ryu, Kosuke Notsu, Maya Kobayashi, Karin Hamaguchi, Takahiro Hiono, Yuichi Ushitani, Yoshihiro Sakoda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Norikazu IsodaLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-Ku, Sapporo 060-0818, Hokkaido, Japan.ORCID 0000-0003-3480-988X
Satoshi SekiguchiCenter for Animal Disease Control, University of Miyazaki, Miyazaki 889-2192, Miyazaki, Japan.ORCID 0000-0003-2066-128X
Chika RyuKirishima Animal Consultation Clinic, Kirishima 899-5102, Kagoshima, Japan.
Kosuke NotsuCenter for Animal Disease Control, University of Miyazaki, Miyazaki 889-2192, Miyazaki, Japan.
Maya KobayashiLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-Ku, Sapporo 060-0818, Hokkaido, Japan.
Karin HamaguchiDepartment of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Miyazaki, Japan.
Takahiro HionoLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-Ku, Sapporo 060-0818, Hokkaido, Japan.
Yuichi UshitaniJapan Agricultural Cooperatives in Miyazaki Prefecture, Miyazaki 880-8556, Miyazaki, Japan.
Yoshihiro SakodaLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-Ku, Sapporo 060-0818, Hokkaido, Japan.ORCID 0000-0001-7021-1688

Funding

The Japan Society for the Promotion of Science 19K06377, 22K06019
6 · The paper itself

Abstract

Bovine viral diarrhea (BVD) is caused by the BVD virus (BVDV) and has been reported worldwide in cattle. To estimate BVDV circulation among cattle where few BVD cases were reported in southern Japan, 1910 serum samples collected from 35 cattle farms without a BVD outbreak were investigated to detect antibodies against BVDV-1 and BVDV-2 using an indicator virus with a cytopathogenic effect and the luciferase gene, respectively. Neutralizing antibodies against BVDV-1 and BVDV-2 were detected more frequently in 18 vaccinated farms than in 17 nonvaccinated farms. In the nonvaccinated farms, 9.6%, 1.8%, and 13.8% of the cattle were estimated to have a history of infection with BVDV-1, BVDV-2, and both, respectively. The median rate of within-herd anti-BVDV-1 seropositivity among cattle in the nonvaccinated farms was 22.0%; however, a high within-herd seropositivity (>50%) was confirmed in the two farms. The force of infection, basic reproduction number, and annual probability of BVDV-1 infection were estimated as 0.072 (95% confidence interval [CI]: 0.062-0.084), 0.36 (95% CI: 0.31-0.42), and 0.73% (95% CI: 0.61-0.87%), respectively, using the age-specific positive rate of anti-BVDV-1 antibodies. These parameters should be further applicable for developing epidemiological models which illustrate the BVDV dynamics in the field.

Indexed as

Antibodies, ViralBovine Virus Diarrhea-Mucosal DiseaseDiarrhea Virus 1, Bovine ViralDiarrhea Virus 2, Bovine ViralDiarrhea Viruses, Bovine ViralAnimalsAntibodies, NeutralizingCattleJapanSeroepidemiologic StudiesVaccinationAntibodies, NeutralizingAntibodies, Viralage stratabasic reproduction numberbovine viral diarrheacattleforce of infectionserological test

Identifiers

PMID39861850
PMCPMC11768412

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.