Evidence map›Paper›PMID 39861824›Full record

ArticleViruses2024

Association Between Single-Nucleotide Polymorphisms in

Adriana Souza Andrade, Aline Almeida Bentes, Lilian Martins Diniz, Silvia Hees Carvalho, Erna Geessien Kroon, Marco Antonio Campos

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. The X-LinkedInternational journal of molecular sciences · 2025
    Article
  5. Analyses of haplotypes ofFrontiers in genetics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adriana Souza AndradeInstituto René Rachou/Fiocruz Minas, Belo Horizonte 30190-009, MG, Brazil.
Aline Almeida BentesDepartamento de Pediatria, Universidade Federal de Minas Gerais, Belo Horizonte 30130-110, MG, Brazil.ORCID 0000-0002-7111-940X
Lilian Martins DinizDepartamento de Pediatria, Universidade Federal de Minas Gerais, Belo Horizonte 30130-110, MG, Brazil.
Silvia Hees CarvalhoInstituto René Rachou/Fiocruz Minas, Belo Horizonte 30190-009, MG, Brazil.ORCID 0000-0001-9329-0411
Erna Geessien KroonLaboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Minas Gerais, Belo Horizonte 31270-201, MG, Brazil.ORCID 0000-0003-2721-3826
Marco Antonio CamposInstituto René Rachou/Fiocruz Minas, Belo Horizonte 30190-009, MG, Brazil.ORCID 0000-0003-4683-0176

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais Parliamentary Inquiry Amendment of deputy Laura Serrano, PPE00040/22-IRR009FEX23National Council for Scientific and Technological Development 0
6 · The paper itself

Abstract

The global number of COVID-19 deaths has reached 7 million, with 4% of these deaths occurring in children and adolescents. In Brazil, around 1500 children up to 11 years old died from the disease. The most common symptoms in children are respiratory, potentially progressing to severe illnesses, such as severe acute respiratory syndrome (SARS) and MIS-C. Studies indicate that comorbidities and genetic factors, such as polymorphisms in immune response genes, can influence the severity of COVID-19. This study investigates the occurrence of single-nucleotide polymorphisms (SNPs) in innate immune response genes in children with COVID-19. Seventy-three samples were analyzed from children under 13 years old hospitalized at João Paulo II Children's Hospital due to COVID-19. The evaluated SNPs were

Indexed as

COVID-19Membrane GlycoproteinsPolymorphism, Single NucleotideReceptors, Interleukin-1Toll-Like Receptor 3Toll-Like Receptor 7Toll-Like Receptor 8AdolescentBrazilChildChild, PreschoolFemaleGenetic Predisposition to DiseaseHumansImmunity, InnateInfantMembrane GlycoproteinsReceptors, Interleukin-1TIRAP protein, humanTLR3 protein, humanTLR7 protein, humanTLR8 protein, humanToll-Like Receptor 3Toll-Like Receptor 7Toll-Like Receptor 8genes innate immunitySARS-CoV2single-nucleotide polymorphismssymptom severity in children presenting COVID-19

Identifiers

PMID39861824
PMCPMC11769468

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.