ArticleViruses2024
eEF-2K Deficiency Boosts the Virus-Specific Effector CD8
Liqing Wang, Benny Shone Song, Rayansh Poojary, Xiaofang Xiong, Xingcong Ren, Jin-Ming Yang, Jianxun Song
Abstract read
In one paragraphArticle in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
7 authors.
Liqing WangDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.ORCID 0009-0000-9896-3793 Benny Shone SongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Rayansh PoojaryDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Xiaofang XiongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Xingcong RenDepartment of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Jin-Ming YangDepartment of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.ORCID 0000-0002-8703-0493 Jianxun SongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.ORCID 0000-0002-9734-6176 Funding
Nucleus Accumbens-Associated Protein-1 in Melanoma ImmunotherapyR01CA221867 · NCI · UNIVERSITY OF KENTUCKY · PI SONG, JIANXUN JIM, YANG, JIN-MING · 2018 to 2023
$2.8MIntegrative Targeted Therapy for MelanomaR01CA282254 · NCI · UNIVERSITY OF KENTUCKY · PI SONG, JIANXUN JIM, YANG, JIN-MING · 2024 to 2025
$1.2MCombating chronic neuroinflammatory disorders by targeting NAC1R21AI167793 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SONG, JIANXUN JIM · 2022 to 2023
$413kNCI NIH HHS R01 CA221867NCI NIH HHS R01 CA282254NIAID NIH HHS R21 AI167793NIH HHS R01CA282254, R01CA221867 and R21AI167793
6 · The paper itselfAbstract
In this study, we revealed a critical role of eukaryotic elongation factor-2 kinase (eEF-2K), a negative regulator of protein synthesis, in regulating T cells during vaccinia virus (VACV) infection. We found that eEF-2K-deficient (eEF-2K⁻/⁻) mice exhibited a significantly higher proportion of VACV-specific effector CD8
Indexed as
CD8-Positive T-LymphocytesElongation Factor 2 KinaseVacciniaVaccinia virusAnimalsImmunologic MemoryMiceMice, Inbred C57BLMice, KnockoutElongation Factor 2 KinaseeEF-2Keffector CD8+ T cellsT cell immunityTRAF3vaccinia virus (VACV)viral infection
Identifiers
PMID39861816
PMCPMC11768472
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