Evidence map›Paper›PMID 39861723›Full record

ArticlePharmaceutics2025

Single Exposure to Low-Intensity Focused Ultrasound Causes Biphasic Opening of the Blood-Brain Barrier Through Secondary Mechanisms.

Tasneem A Arsiwala, Kathryn E Blethen, Cullen P Wolford, Geoffrey L Pecar, Dhruvi M Panchal, Brooke N Kielkowski, Peng Wang, Manish Ranjan, Jeffrey S Carpenter, Victor Finomore and 2 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tasneem A ArsiwalaDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, USA.ORCID 0000-0002-5799-0514
Kathryn E BlethenDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, USA.ORCID 0000-0003-4602-9514
Cullen P WolfordDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, USA.
Geoffrey L PecarDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, USA.
Dhruvi M PanchalDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, USA.ORCID 0000-0002-2395-0397
Brooke N KielkowskiDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, USA.
Peng WangDepartment of Neuroscience, West Virginia University School of Medicine, Rockefeller Neuroscience Institute, Morgantown, WV 26505, USA.
Manish RanjanDepartment of Neuroscience, West Virginia University School of Medicine, Rockefeller Neuroscience Institute, Morgantown, WV 26505, USA.ORCID 0000-0002-3338-8676
Jeffrey S CarpenterDepartment of Neuroscience, West Virginia University School of Medicine, Rockefeller Neuroscience Institute, Morgantown, WV 26505, USA.ORCID 0000-0001-6966-7987
Victor FinomoreDepartment of Neuroscience, West Virginia University School of Medicine, Rockefeller Neuroscience Institute, Morgantown, WV 26505, USA.
Ali RezaiDepartment of Neuroscience, West Virginia University School of Medicine, Rockefeller Neuroscience Institute, Morgantown, WV 26505, USA.
Paul R LockmanDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, USA.ORCID 0000-0002-6995-9944

Funding

WVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Rachel M. Abbotts · 2018 to 2026
$22.4M
Translational use of focused ultrasound to increase blood-tumor barrier permeability as a mechanism to increase drug accumulation into brain metastases of breast cancerF99CA264445 · NCI · WEST VIRGINIA UNIVERSITY · PI ARSIWALA, TASNEEM · 2021 to 2022
$85k
MetaVivor N/AMylan Chair Endowment NANCI NIH HHS 1F99CA264445-01NCI NIH HHS F99 CA264445NIGMS NIH HHS P20 GM121322NIGMS NIH HHS P20GM121322NIGMS NIH HHS P20GM121322-03S1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

blood–brain barrier (BBB) disruptionlow-intensity focused ultrasound (LiFUS)neuroinflammationP-glycoprotein (P-gp)vascular permeability

Identifiers

PMID39861723
PMCPMC11768402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.