Evidence map›Paper›PMID 39861669›Full record

ArticlePharmaceutics2024

Pharmacokinetic Evaluation of Neutral Sphinghomyelinase2 (nSMase2) Inhibitor Prodrugs in Mice and Dogs.

Arina Ranjit, Chae Bin Lee, Lukáš Tenora, Vijaya Saradhi Mettu, Arindom Pal, Jesse Alt, Barbara S Slusher, Rana Rais

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arina RanjitDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Chae Bin LeeDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4551-9191
Lukáš TenoraDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-6982-3545
Vijaya Saradhi MettuDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Arindom PalDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Jesse AltDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Barbara S SlusherDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-9814-4157
Rana RaisDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4059-2453

Funding

Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Leah Helane Rubin · 2006 to 2026
$33.2M
Dendrimer-conjugated nSMase2 inhibitor as a novel therapeutic approach for Alzheimer's DiseaseR01AG063831 · NIA · JOHNS HOPKINS UNIVERSITY · PI RAIS, RANA, RANGARAMANUJAM, KANNAN · 2020 to 2024
$2.3M
National Institute of Health RO1AG063831NIA NIH HHS R01 AG063831NIMH NIH HHS P30 MH075673NIMH NIH HHS P30MH075673
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

dog pharmacokineticsDPTIPmice pharmacokineticsnSMase2oral bioavailabilityprodrug

Identifiers

PMID39861669
PMCPMC11768932

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.