Evidence map›Paper›PMID 39861475›Full record

ArticleNutrients2025

The Association Between Adherence to the Mediterranean Diet and Depression and Anxiety Symptoms in University Students: The Mediating Role of Lean Mass and the Muscle Strength Index.

Sofía Alfaro-González, Miriam Garrido-Miguel, Carlos Pascual-Morena, Diana P Pozuelo-Carrascosa, Rubén Fernández-Rodríguez, José Alberto Martínez-Hortelano, Arthur E Mesas, Vicente Martínez-Vizcaíno

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sofía Alfaro-GonzálezHealth and Social Research Center, Universidad de Castilla La-Mancha, 16071 Cuenca, Spain.ORCID 0000-0001-9726-8377
Miriam Garrido-MiguelHealth and Social Research Center, Universidad de Castilla La-Mancha, 16071 Cuenca, Spain.ORCID 0000-0003-4617-616X
Carlos Pascual-MorenaHealth and Social Research Center, Universidad de Castilla La-Mancha, 16071 Cuenca, Spain.ORCID 0000-0003-1154-8752
Diana P Pozuelo-CarrascosaHealth and Social Research Center, Universidad de Castilla La-Mancha, 16071 Cuenca, Spain.ORCID 0000-0002-0527-5498
Rubén Fernández-RodríguezHealth and Social Research Center, Universidad de Castilla La-Mancha, 16071 Cuenca, Spain.ORCID 0000-0001-7504-1534
José Alberto Martínez-HortelanoCuidado Comunitario y Determinantes Sociales de la Salud, Enfermería, Departamento de Enfermería y Fisioterapia, Facultad de Enfermería y Fisioterapia, Universidad de Alcalá, 28801 Madrid, Spain.
Arthur E MesasHealth and Social Research Center, Universidad de Castilla La-Mancha, 16071 Cuenca, Spain.ORCID 0000-0002-0088-8607
Vicente Martínez-VizcaínoHealth and Social Research Center, Universidad de Castilla La-Mancha, 16071 Cuenca, Spain.ORCID 0000-0001-6121-7893

Funding

Supported by the Carlos III Health Institute, Spain, FEDER funds and cofunded by the European Union's NextGenerationEU initiative PI21/01898the Spanish Ministry of Science, Innovation and Universities, co-financed by the European Social Fund+ JDC2023-050585-I, MCIU/AEI/10.13039/501100011033
6 · The paper itself

Abstract

BACKGROUND/

objectivesrecent studies have suggested that components typical of the Mediterranean diet (MedDiet) are associated with depression and anxiety prevention. In this sense, the main objective of this study was to analyse the associations between adherence to the MedDiet and depression and anxiety symptoms and to examine whether this relationship is mediated by lean mass and the muscle strength index (MSI).

methodsa cross-sectional study (based on data obtained from the Nuts4Brain-Z study) was conducted from 2023-2024, involving 428 university students, aged 18-30 years, from a Spanish public university. Depression was assessed using the Beck Depression Inventory (BDI-II), and anxiety was assessed via the General Anxiety Disorder-7 (GAD-7) tool. Adherence to the MedDiet was assessed using the MEDAS questionnaire. Lean mass was assessed via bioimpedance, and MSI was measured via a dynamometer. ANCOVA models were used to test the mean differences in depression and anxiety scores using MEDAS categories (low adherence < 9 points vs high adherence ≥ 9 points). Serial multiple mediation models, adjusted for the main confounders, were used to explore the role of lean mass and MSI in the relationships between adherence to the MedDiet and depression and anxiety symptoms.

resultsuniversity students with high adherence to the MedDiet exhibited lower scores for depression and anxiety symptoms (

conclusionadherence to the MedDiet in university students per se does not appear to have a direct effect on depression and anxiety symptoms because these associations are partially (for depression) or entirely (for anxiety) explained by lean mass and MSI.

Indexed as

AnxietyDepressionDiet, MediterraneanMuscle StrengthPatient ComplianceStudentsAdolescentAdultBody CompositionCross-Sectional StudiesFemaleHumansMaleSpainUniversitiesYoung AdultMediterranean dietary patternmental healthphysical fitnessyoung adults

Identifiers

PMID39861475
PMCPMC11768187

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.