Evidence map›Paper›PMID 39861474›Full record

ArticleNutrients2025

Nutrient-Nutrient Interactions Among Broccoli Glucosinolates and Their Implications for Breeding Cruciferous Crops to Enhance Human Health.

Weston Bussler, Katelyn DeZego, Holli Chandler, Robert W Reid, Slavko Komarnytsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weston BusslerPlants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, USA.
Katelyn DeZegoPlants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, USA.
Holli ChandlerPlants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, USA.
Robert W ReidDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, 150 N Research Campus Dr, Kannapolis, NC 28081, USA.ORCID 0000-0001-7125-7151
Slavko KomarnytskyPlants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, USA.ORCID 0000-0003-4665-4993

Funding

USDA 1023927
6 · The paper itself

Abstract

While a balanced diet can fulfill most nutritional needs, optimizing the composition of specific foods like broccoli can amplify their health benefits. BACKGROUND/

objectivesBroccoli (

methodsThis study investigated mixtures of four major aliphatic glucosinolates-glucoraphanin, gluconapin, progoitrin, and sinigrin-in individual and combinational models to assess their effects on human colorectal cell proliferation.

resultsCombination index analysis revealed moderate to strong antagonistic interactions among these glucosinolates, with the most significant antagonism observed during enzymatic hydrolysis by myrosinase. Mixture analysis identified an optimal glucosinolate ratio including glucoraphanin (81-84%), gluconapin (9-19%), and others (0-7%) to maximize their antiproliferative effects (adjusted R

conclusionsThis study highlights the potential of leveraging nutrient-nutrient interactions to guide molecular breeding and produce functional varieties of cruciferous vegetables with optimized health benefits.

Indexed as

BrassicaGlucosinolatesNutrientsPlant BreedingCell Line, TumorCell ProliferationGlycoside HydrolasesHumansImidoestersIsothiocyanatesNutritive ValueOximesSulfoxidesglucoraphaninGlucosinolatesGlycoside HydrolasesImidoestersIsothiocyanatesNutrientsOximessinigrinSulfoxidesthioglucosidasebreedingcell proliferationchemopreventioncolonglucosinolate profilemixture analysisnutrient interactionsvegetableswhole foods

Identifiers

PMID39861474
PMCPMC11768351

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.