Evidence map›Paper›PMID 39861429›Full record

Observational studyNutrients2025

An Assessment of Intermittent and Continuous Enteral Feeding in Critically Ill Children.

Merve Misirlioglu, Dincer Yildizdas, Faruk Ekinci, Nihal Akcay, Ilyas Bingol, Ebru Sahin, Fatih Varol, Muhterem Duyu, Ayse Asik, Fatih Durak and 42 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors.

Merve MisirliogluDepartment of Pediatric Intensive Care, Faculty of Medicine, Mersin University, Mersin 33079, Türkiye.ORCID 0000-0002-9554-841X
Dincer YildizdasDepartment of Pediatric Intensive Care, Faculty of Medicine, Cukurova University, Adana 01790, Türkiye.
Faruk EkinciDepartment of Pediatric Intensive Care, Faculty of Medicine, Cukurova University, Adana 01790, Türkiye.
Nihal AkcayDepartment of Pediatric Intensive Care, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul 34303, Türkiye.ORCID 0000-0002-8273-2226
Ilyas BingolDepartment of Pediatric Intensive Care, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul 34303, Türkiye.
Ebru SahinDepartment of Pediatric Intensive Care, Sancaktepe Prof. Dr. Ilhan Varank Training & Research Hospital, Istanbul 34785, Türkiye.ORCID 0000-0002-7532-7724
Fatih VarolDepartment of Pediatric Intensive Care, Sancaktepe Prof. Dr. Ilhan Varank Training & Research Hospital, Istanbul 34785, Türkiye.
Muhterem DuyuDepartment of Pediatric Intensive Care, Medeniyet University Prof. Dr. Suleyman Yalcin City Hospital, Istanbul 34722, Türkiye.
Ayse AsikDepartment of Pediatric Intensive Care, Medeniyet University Prof. Dr. Suleyman Yalcin City Hospital, Istanbul 34722, Türkiye.ORCID 0000-0003-0973-8098
Fatih DurakDepartment of Pediatric Intensive Care, Izmir City Hospital, Izmir 35540, Türkiye.
Leyla AtmanDepartment of Pediatric Intensive Care, Izmir City Hospital, Izmir 35540, Türkiye.
Suleyman BayraktarDepartment of Pediatric Intensive Care, Sultangazi Haseki Training and Research Hospital, Istanbul 34260, Türkiye.ORCID 0000-0002-8080-2438
Mehmet AlakayaDepartment of Pediatric Intensive Care, Faculty of Medicine, Mersin University, Mersin 33079, Türkiye.
Ali Ertug ArslankoyluDepartment of Pediatric Intensive Care, Faculty of Medicine, Mersin University, Mersin 33079, Türkiye.
Gurkan BozanDepartment of Pediatric Intensive Care, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir 26480, Türkiye.ORCID 0000-0001-5041-8892
Eylem KiralDepartment of Pediatric Intensive Care, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir 26480, Türkiye.ORCID 0000-0003-2245-5340
Ozden Ozgur HorozDepartment of Pediatric Intensive Care, Faculty of Medicine, Cukurova University, Adana 01790, Türkiye.
Hasan Ali TelefonDepartment of Pediatric Intensive Care, Faculty of Medicine, Cukurova University, Adana 01790, Türkiye.
Abdullah AkkusDepartment of Pediatric Intensive Care, Faculty of Medicine, Necmettin Erbakan University, Konya 42090, Türkiye.
Abdullah YazarDepartment of Pediatric Intensive Care, Faculty of Medicine, Necmettin Erbakan University, Konya 42090, Türkiye.ORCID 0000-0003-0733-3943
Ozlem SandalDepartment of Pediatric Intensive Care, University of Health Sciences Izmir Dr. Behcet Uz Child Diseases and Surgery Training and Research Hospital, Izmir 35210, Türkiye.
Hasan AginDepartment of Pediatric Intensive Care, University of Health Sciences Izmir Dr. Behcet Uz Child Diseases and Surgery Training and Research Hospital, Izmir 35210, Türkiye.
Alper KokerDepartment of Pediatric Intensive Care, Faculty of Medicine, Akdeniz University, Antalya 07070, Türkiye.ORCID 0000-0003-1231-3023
Nazan Ulgen TekerekDepartment of Pediatric Intensive Care, Faculty of Medicine, Akdeniz University, Antalya 07070, Türkiye.ORCID 0000-0002-4577-1488
Nurettin Onur KutluDepartment of Pediatric Intensive Care, Basaksehir Cam ve Sakura City Hospital, Istanbul 34480, Türkiye.ORCID 0000-0002-3306-6570
Mehmet Arda KilincDepartment of Pediatric Intensive Care, Basaksehir Cam ve Sakura City Hospital, Istanbul 34480, Türkiye.
Ali KorulmazDepartment of Pediatric Intensive Care, Kocaeli City Hospital, Kocaeli 41060, Türkiye.
Hatice Feray AriDepartment of Pediatric Intensive Care, Faculty of Medicine, Adnan Menderes University, Aydın 09010, Türkiye.ORCID 0000-0002-2208-2524
Mutlu Uysal YaziciDepartment of Pediatric Intensive Care, Faculty of Medicine, Gazi University, Ankara 06560, Türkiye.
Esra SevketogluDepartment of Pediatric Intensive Care, Basaksehir Cam ve Sakura City Hospital, Istanbul 34480, Türkiye.
Mehmet Emin MenentogluDepartment of Pediatric Intensive Care, University of Health Sciences Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul 34147, Türkiye.
Ebru KacmazDepartment of Pediatric Intensive Care, Bursa Dortcelik Children Hospital, Bursa 16120, Türkiye.
Mehmet Nur TalayDepartment of Pediatric Intensive Care, Mardin Artuklu University, Mardin Training & Research Hospital, Mardin 47100, Türkiye.
Ozhan OrhanDepartment of Pediatric Intensive Care, Mardin Artuklu University, Mardin Training & Research Hospital, Mardin 47100, Türkiye.
Berna Egehan OruncuDepartment of Pediatric Intensive Care, Life Support Center, Faculty of Medicine, Hacettepe University, Ankara 06230, Türkiye.
Selman KesiciDepartment of Pediatric Intensive Care, Life Support Center, Faculty of Medicine, Hacettepe University, Ankara 06230, Türkiye.
Caglar OdekDepartment of Pediatric Intensive Care, Faculty of Medicine, Bursa Uludağ University, Bursa 16285, Türkiye.
Didar ArslanDepartment of Pediatric Intensive Care, Faculty of Medicine, Bursa Uludağ University, Bursa 16285, Türkiye.
Pinar HepdumanDepartment of Pediatric Intensive Care, Erzurum City Hospital, Erzurum 25240, Türkiye.ORCID 0000-0001-7305-9984
Gultac EvrenDepartment of Pediatric Intensive Care, Manisa City Hospital, Manisa 45040, Türkiye.ORCID 0000-0002-0614-0894
Hatice Elif Kinik KayaDepartment of Pediatric Intensive Care, Faculty of Medicine, Ondokuz Mayıs University, Samsun 55270, Türkiye.
Nazik YenerDepartment of Pediatric Intensive Care, Faculty of Medicine, Ondokuz Mayıs University, Samsun 55270, Türkiye.
Emrah GunDepartment of Pediatric Intensive Care, Ankara Etlik City Hospital, Ankara 06170, Türkiye.ORCID 0000-0001-7337-0190
Ilkem GardiyanogluDepartment of Pediatric Intensive Care, Ankara Etlik City Hospital, Ankara 06170, Türkiye.
Muhammed UdurgucuDepartment of Pediatric Intensive Care, Samsun Training & Research Hospital, Samsun 55090, Türkiye.
Sinan YavuzDepartment of Pediatric Intensive Care, Batman Training & Research Hospital, Batman 72070, Türkiye.
Ali AvciDepartment of Pediatric Intensive Care, Batman Training & Research Hospital, Batman 72070, Türkiye.
Murat OzkaleDepartment of Pediatric Intensive Care, Faculty of Medicine, Baskent University, Adana Dr. Turgut Noyan Teaching and Medical Research Center, Adana 01250, Türkiye.
Yasemin OzkaleDepartment of Pediatric Intensive Care, Faculty of Medicine, Baskent University, Adana Dr. Turgut Noyan Teaching and Medical Research Center, Adana 01250, Türkiye.
Damla Pinar Yavas KocaogluDepartment of Pediatric Intensive Care, Health Sciences University Gulhane Training and Research Hospital, Ankara 06018, Türkiye.
Sahin SincarDepartment of Pediatric Intensive Care, Health Sciences University Gulhane Training and Research Hospital, Ankara 06018, Türkiye.
Yasemin CobanDepartment of Pediatric Intensive Care, Faculty of Medicine, Mugla Sitki Kocman University, Mugla 48000, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe inability to ensure adequate nutrition for patients, and failure to provide adequate calorie and protein intake, result in malnutrition, leading to increased morbidity and mortality. The present study assesses the two approaches to enteral nutrition-intermittent and continuous enteral feeding-in critically ill pediatric patients in Türkiye to determine the superiority of one method over the other.

methodsIncluded in this multicenter prospective study were patients receiving enteral nutrition via a tube who were followed up over a 3-month period. Anthropometric data, calorie and protein intake, and signs of feeding intolerance were evaluated in a comparison of the different feeding methods.

resultsA total of 510 patients were examined. In the continuous enteral feeding (CEF) group, 20.2% of patients developed metabolic abnormalities, and 49.5% experienced enteral nutrition intolerance, both of which were higher than in the intermittent enteral feeding (IEF) group, and the differences were statistically significant. No significant differences were observed between the two feeding methods in terms of reaching the target calorie intake on days 2 and 7 (

conclusionsIn the present study, assessing the IEF and CEF approaches to enteral nutrition, critically ill pediatric patients receiving intermittent feeding exhibited lower rates of enteral nutrition intolerance and metabolic abnormalities. Furthermore, the calorie and protein intake on day 7 were noted to be higher in the IEF group than in the CEF group. Further randomized controlled trials are needed to confirm the findings of the present study.

Indexed as

Critical IllnessEnteral NutritionAdolescentChildChild, PreschoolDietary ProteinsEnergy IntakeFemaleHumansInfantMaleProspective StudiesDietary Proteinscontinuous feedingenteral nutritionintermittent feedingpediatric

Identifiers

PMID39861429
PMCPMC11767559

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.