SynthesisNutrients2025
Effects of D-Tagatose on Cariogenic Risk: A Systematic Review of Randomized Clinical Trials.
Synthesis in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- On-demand caries prevention: on-site generated slightly acidic electrolyzed water as a potent and biocompatible anti- Streptococcus mutans agent.BMC oral health · 2026Article
- Tagatose attenuates streptococcus mutans-induced dental caries by modulating oral microbiota and inflammatory responses in mice.BMC microbiology · 2026Article
- Correction: Angarita-Davila et al. Effects of D-Tagatose on Cariogenic Risk: A Systematic Review of Randomized Clinical Trials.Nutrients · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental caries remains a prevalent chronic disease driven by dysbiosis in the oral biofilm, with
objectiveThis study aimed to assess the effect of D-tagatose on cariogenic risk by analyzing randomized clinical trials (RCTs).
methodsA systematic literature review was conducted targeting RCTs published up to 2024 in eight databases and two gray literature sources. The search strategy utilized Medical Subject Headings (MeSHs) and relevant keywords combined via Boolean operators using the query "Tagatose OR D-tagatose AND Dental Caries". Eligible studies must evaluate the impact of D-tagatose on cariogenic risk, as indicated by reductions in colony-forming units (CFUs) and/or improvements in salivary pH levels in treatment groups.
resultsFrom 1139 retrieved records, three studies met the inclusion criteria. Two of these studies consistently demonstrated significant reductions in CFU counts in vitro and changes in oral bacteria in groups treated with D-tagatose alone or in mixtures with other agents compared to controls using other non-caloric sweeteners or placebos (
conclusionsAlthough the findings suggest potential benefits of D-tagatose in reducing cariogenic risk, limitations such as small sample sizes and variability in study methodologies warrant caution. Further robust investigations are needed to substantiate these promising results and support the integration of D-tagatose into oral care formulations aimed at reducing cariogenic risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.