Evidence map›Paper›PMID 39861404›Full record

ArticleNutrients2025

Phytochemical Composition and Antioxidant Activity of Manuka Honey and Ohia Lehua Honey.

Iulia Ioana Morar, Raluca Maria Pop, Erik Peitzner, Floricuța Ranga, Meda Sandra Orăsan, Andra Diana Cecan, Elisabeta Ioana Chera, Teodora Irina Bonci, Lia Oxana Usatiuc, Mădălina Țicolea and 4 more

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Molecules (Basel, Switzerland) · 2026
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  10. Multitargeted Effects ofInternational journal of molecular sciences · 2025
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Iulia Ioana MorarPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Raluca Maria PopPharmacology, Toxicology and Clinical Pharmacology, Department of Morpho-Functional Sciences, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0003-1899-5977
Erik PeitznerPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Floricuța RangaFood Science and Technology, Department of Food Science, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăștur, No 3-5, 400372 Cluj-Napoca, Romania.
Meda Sandra OrăsanPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Andra Diana CecanPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Elisabeta Ioana CheraPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Teodora Irina BonciPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Lia Oxana UsatiucPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Mădălina ȚicoleaPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Anca Elena ButPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Florinela Adriana CătoiPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Alina Elena PârvuPathophysiology, Department of Morpho-Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.ORCID 0000-0002-9052-6844
Mircea Constantin Dinu GhergieOrthodontics, Department of Conservative Odontology, Faculty of Dental Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Honey is abundant in bioactive compounds, which demonstrate considerable therapeutic effects, particularly on oxidative stress and inflammation.

objectivesThis work sought to evaluate the antioxidant mechanisms of Manuka honey (MH) and Ohia Lehua honey (OLH), correlating them with phytochemical analyses in a rat model of experimentally induced inflammation.

methodsThe identification of polyphenolic compounds in the extracts was carried out using HPLC-ESI MS. The extracts' antioxidant activity was evaluated in vitro through DPPH, FRAP, H

resultsThe phytochemical analysis found a rich content of phenolic compounds in MH and lower quantities in OLH. In terms of in vitro activity, both MH and OLH exhibited strong DPPH radical scavenging abilities, effective NO and H

conclusionsTo our knowledge, this is the first study to assess the phenolic content of OLH and to show its capacity to scavenge free radicals and reduce oxidative stress. The effectiveness of MH primarily relies on its increased antioxidant properties and depends on concentration. These results highlight the importance of investigating natural products in developing antioxidant strategies.

Indexed as

AntioxidantsHoneyLeptospermumPhytochemicalsAnimalsInflammationMaleNitric OxideOxidative StressPolyphenolsRatsRats, WistarAntioxidantsNitric OxidePhytochemicalsPolyphenolsantioxidantinflammationManuka honeyOhia Lehua honeyoxidative stresspolyphenols

Identifiers

PMID39861404
PMCPMC11767333

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.