Mechanical Properties and Decomposition Behavior of Compression Moldable Poly(Malic Acid)/

Shuta Hara, Akiko Kojima, Atsushi Furukawa, Takeshi Toyama, Hiroki Ikake, Shigeru Shimizu, Kimio Kurita

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Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Shuta HaraDepartment of Material and Life Chemistry, Kanagawa University, 3-6-1, Kanagawa-ku, Yokohama 221-8686, Japan.

Akiko KojimaDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kandasurugadai, Chiyoda-ku, Tokyo 101-8308, Japan.

Atsushi FurukawaDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kandasurugadai, Chiyoda-ku, Tokyo 101-8308, Japan.

Takeshi ToyamaDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kandasurugadai, Chiyoda-ku, Tokyo 101-8308, Japan.ORCID 0000-0002-2480-3153

Hiroki IkakeDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kandasurugadai, Chiyoda-ku, Tokyo 101-8308, Japan.ORCID 0000-0001-8955-2263

Shigeru ShimizuDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kandasurugadai, Chiyoda-ku, Tokyo 101-8308, Japan.

Kimio KuritaDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kandasurugadai, Chiyoda-ku, Tokyo 101-8308, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcified tissues in living organisms, such as bone, dentin, and enamel, often require surgical intervention for treatment. However, advances in regenerative medicine have increased the demand for materials to assist in regenerating these tissues. Among the various forms of calcium phosphate (CaP), tricalcium phosphate (TCP)-particularly its α-TCP form-stands out due to its high solubility and efficient calcium release, making it a promising candidate for bone regeneration applications. Nevertheless, its rapid dissolution rate presents challenges when used as a reinforcing agent. In this study, we developed a hybrid material composed of poly(malic acid) (PMA) and α-TCP to achieve controlled calcium release while maintaining mechanical strength. The hybrid materials were prepared using a compression molding method optimized to suppress the hydrolysis of PMA. The bond between the carboxyl group of PMA and α-TCP was confirmed through infrared (IR) spectroscopy. A calcium release test demonstrated that the interaction between PMA and α-TCP extends the dissolution period of both components. These findings indicate that PMA/α-TCP hybrid materials have significant potential for applications in bone tissue engineering.

Indexed as

Hybrid materialsPoly(malic acid)The bone tissue materialα-Tricalcium phosphate

Identifiers

PMID39861221

DOI10.3390/polym17020147

PMCPMC11768388

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