Evidence map›Paper›PMID 39861102›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Chemical Characterization and Differential Lipid-Modulating Effects of Selected Plant Extracts from Côa Valley (Portugal) in a Cell Model for Liver Steatosis.

Ricardo Amorim, Mário Pedro Marques, Catarina Melim, Carla Varela, Vilma A Sardão, José Teixeira, Maria Inês Dias, Lillian Barros, Paulo J Oliveira, Célia Cabral

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ricardo AmorimClinic Academic Center of Coimbra (CACC), Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, 3000-548 Coimbra, Portugal.
Mário Pedro MarquesClinic Academic Center of Coimbra (CACC), Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-5414-366X
Catarina MelimClinic Academic Center of Coimbra (CACC), Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, 3000-548 Coimbra, Portugal.
Carla VarelaClinic Academic Center of Coimbra (CACC), Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-9824-4753
Vilma A SardãoCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0001-7014-4614
José TeixeiraCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.
Maria Inês DiasMountain Research Centre (CIMO), Polytechnic Institute of Bragança (IPB), Campus Santa Apolónia, 5300-253 Bragança, Portugal.ORCID 0000-0001-8744-7814
Lillian BarrosMountain Research Centre (CIMO), Polytechnic Institute of Bragança (IPB), Campus Santa Apolónia, 5300-253 Bragança, Portugal.ORCID 0000-0002-9050-5189
Paulo J OliveiraCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.
Célia CabralClinic Academic Center of Coimbra (CACC), Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0003-4562-6683

Funding

Foundation for Science and Technology (FCT, Portugal) CôaMedPlants project: COA/BRB/0019/2019 - DOI: 10.54499/COA/BRB/0019/2019Foundation for Science and Technology (FCT, Portugal) LA/P/0058/2020 - DOI: 10.54499/UIDP/04539/2020Foundation for Science and Technology (FCT, Portugal) SusTEC (LA/P/0007/2020)Foundation for Science and Technology (FCT, Portugal) UIDB/00690/2020Foundation for Science and Technology (FCT, Portugal) UIDB/04539/2020 - DOI: 10.54499/UIDB/04539/2020Foundation for Science and Technology (FCT, Portugal) UIDP/00690/2020Foundation for Science and Technology (FCT, Portugal) UIDP/04539/2020 - DOI: 10.54499/UIDP/04539/2020
6 · The paper itself

Abstract

BACKGROUND/

objectivesCôa Valley, located in the northeast of Portugal, harbors more than 500 medicinal plant species. Among them, four species stand out due to their traditional uses:

methodsDecoction (D) and hydroalcoholic (EtOH80%) extracts were prepared and chemically characterized. Their safety profile and effects on lipid accumulation were assessed in palmitic acid (PA)-treated HepG2 cells using resazurin, sulforhodamine B, and Nile Red assays.

resultsChemical analysis revealed diverse phenolic compounds, particularly kaempferol derivatives in

conclusionsThese findings highlight

Indexed as

Côa Valley (Portugal)Equisetum ramosissimum Desf.lipid-lowering effectMASLDplant extracts

Identifiers

PMID39861102
PMCPMC11768118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.