Evidence map›Paper›PMID 39860395›Full record

ReviewJournal of clinical medicine2025

Diagnostic Approach to Pneumonia in Immunocompromised Hosts.

Nadir Ullah, Ludovica Fusco, Luigi Ametrano, Claudia Bartalucci, Daniele Roberto Giacobbe, Antonio Vena, Malgorzata Mikulska, Matteo Bassetti

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nadir UllahDepartment of Health Sciences (DISSAL), University of Genoa, 16126 Genoa, Italy.ORCID 0000-0003-0030-7953
Ludovica FuscoUO Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, 16126 Genoa, Italy.
Luigi AmetranoUO Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, 16126 Genoa, Italy.ORCID 0000-0002-4181-4938
Claudia BartalucciDepartment of Health Sciences (DISSAL), University of Genoa, 16126 Genoa, Italy.ORCID 0009-0000-1940-5620
Daniele Roberto GiacobbeDepartment of Health Sciences (DISSAL), University of Genoa, 16126 Genoa, Italy.ORCID 0000-0003-2385-1759
Antonio VenaDepartment of Health Sciences (DISSAL), University of Genoa, 16126 Genoa, Italy.ORCID 0000-0002-0697-3992
Malgorzata MikulskaDepartment of Health Sciences (DISSAL), University of Genoa, 16126 Genoa, Italy.ORCID 0000-0002-5535-4602
Matteo BassettiDepartment of Health Sciences (DISSAL), University of Genoa, 16126 Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In immunocompromised patients, pneumonia presents a diagnostic challenge due to diverse etiologies, nonspecific symptoms, overlapping radiological presentation, frequent co-infections, and the potential for rapid progression to severe disease. Thus, timely and accurate diagnosis of all pathogens is crucial. This narrative review explores the latest advancements in microbiological diagnostic techniques for pneumonia in immunocompromised patients. It covers major available microbiological tools for diagnosing both community-acquired and hospital-acquired pneumonia, encompassing a wide spectrum of pathogens including bacterial, viral, fungal, and parasitic. While traditional culture methods remain pivotal in identifying many pneumonia-causing etiologies, their limitations in sensitivity and time to results have led to the rise of non-invasive antigen tests and molecular diagnostics. These are increasingly employed alongside cultures and microscopy for more efficient diagnosis, mainly in viral and fungal infections. Lastly, we report the future of pneumonia diagnostics, exploring the potential of metagenomics and CRISPR/Cas13a for more precise and rapid pathogen detection in immunocompromised populations.

Indexed as

antigenic testscultureimmunocompromised patientsmicrobiological diagnosispneumoniapolymerase chain reaction

Identifiers

PMID39860395
PMCPMC11765643

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.