Evidence map›Paper›PMID 39860329›Full record

ReviewJournal of clinical medicine2025

Medical Digital Twin: A Review on Technical Principles and Clinical Applications.

Mario Tortora, Francesco Pacchiano, Suely Fazio Ferraciolli, Sabrina Criscuolo, Cristina Gagliardo, Katya Jaber, Manuel Angelicchio, Francesco Briganti, Ferdinando Caranci, Fabio Tortora and 1 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Evidence-Based Medicine: Past, Present, Future.Journal of clinical medicine · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mario TortoraDepartment of Advanced Biomedical Sciences, University "Federico II", Via Pansini, 5, 80131 Naples, Italy.ORCID 0000-0002-4745-3061
Francesco PacchianoDepartment of Precision Medicine, University of Campania "L. Vanvitelli", 80131 Caserta, Italy.ORCID 0000-0002-4049-3378
Suely Fazio FerraciolliDepartment of Radiology, Massachusetts General Hospital, Boston, MA 02115, USA.ORCID 0000-0001-5687-4186
Sabrina CriscuoloPediatric University Department, Bambino Gesù Children Hospital, 00165 Rome, Italy.
Cristina GagliardoPediatric Department, Ospedale San Giuseppe Moscati, 83100 Aversa, Italy.
Katya JaberDepartment of Elektrotechnik und Informatik, Hochschule Bremen, 28199 Bremen, Germany.
Manuel AngelicchioBiotechnology Department, University of Naples "Federico II", 80138 Napoli, Italy.
Francesco BrigantiDepartment of Advanced Biomedical Sciences, University "Federico II", Via Pansini, 5, 80131 Naples, Italy.
Ferdinando CaranciDepartment of Precision Medicine, University of Campania "L. Vanvitelli", 80131 Caserta, Italy.
Fabio TortoraDepartment of Advanced Biomedical Sciences, University "Federico II", Via Pansini, 5, 80131 Naples, Italy.
Alberto NegroNeuroradiology Unit, Ospedale del Mare ASL NA1 Centro, 80145 Naples, Italy.ORCID 0000-0002-7904-1563

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The usage of digital twins (DTs) is growing across a wide range of businesses. The health sector is one area where DT use has recently increased. Ultimately, the concept of digital health twins holds the potential to enhance human existence by transforming disease prevention, health preservation, diagnosis, treatment, and management. Big data's explosive expansion, combined with ongoing developments in data science (DS) and artificial intelligence (AI), might greatly speed up research and development by supplying crucial data, a strong cyber technical infrastructure, and scientific know-how. The field of healthcare applications is still in its infancy, despite the fact that there are several DT programs in the military and industry. This review's aim is to present this cutting-edge technology, which focuses on neurology, as one of the most exciting new developments in the medical industry. Through innovative research and development in DT technology, we anticipate the formation of a global cooperative effort among stakeholders to improve health care and the standard of living for millions of people globally.

Indexed as

cardiologydigital twinhealthcareneuroscienceoncology

Identifiers

PMID39860329
PMCPMC11765765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.