ArticleMolecules (Basel, Switzerland)2025
6-Bromoindole- and 6-Bromoindazole-Based Inhibitors of Bacterial Cystathionine γ-Lyase Containing 3-Aminothiophene-2-Carboxylate Moiety.
Roman A Novikov, Dmitry N Platonov, Alexander Yu Belyy, Konstantin V Potapov, Maxim A Novikov, Yury V Tomilov, Olga I Kechko, Tatiana A Seregina, Anastasia S Zemskaya, Pavel N Solyev and 1 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Roman A NovikovEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia.
Dmitry N PlatonovZelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, 47 Leninsky Avenue, Moscow 119991, Russia.ORCID 0000-0002-9331-7319 Alexander Yu BelyyZelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, 47 Leninsky Avenue, Moscow 119991, Russia.ORCID 0000-0002-4948-6238 Konstantin V PotapovEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia.ORCID 0000-0003-3819-2418 Maxim A NovikovEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia.ORCID 0000-0002-7259-494X Yury V TomilovZelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, 47 Leninsky Avenue, Moscow 119991, Russia.ORCID 0000-0002-3433-7571 Olga I KechkoEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia.
Tatiana A SereginaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia.ORCID 0000-0003-3278-0390 Anastasia S ZemskayaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia.ORCID 0000-0002-0332-5105 Pavel N SolyevEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia.ORCID 0000-0002-5546-4975 Vladimir A MitkevichEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia.ORCID 0000-0002-1517-1983 Funding
Ministry of Science and Higher Education of the Russian Federation agreement No. 075-10-2021-113, unique project ID RF----193021X0001
6 · The paper itselfAbstract
In recent years, a number of synthetic potentiators of antibiotics have been discovered. Their action can significantly enhance the antibacterial effect and limit the spread of antibiotic resistance through inhibition of bacterial cystathionine-γ-lyase. To expand the known set of potentiators, we developed methods for the synthesis of five new representatives of 6-bromoindole derivatives-potential inhibitors of bacterial cystathionine-γ-lyase-namely potassium 3-amino-5-((6-bromoindolyl)methyl)thiophene-2-carboxylate (
Indexed as
Anti-Bacterial AgentsCystathionine gamma-LyaseEnzyme InhibitorsIndazolesIndolesThiophenesMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsCystathionine gamma-LyaseEnzyme InhibitorsIndazolesIndolesThiophenes6-bromoindazole6-bromoindoleantibiotic potentiators
Identifiers
PMID39860254
PMCPMC11767297
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