Evidence map›Paper›PMID 39860203›Full record

ArticleMolecules (Basel, Switzerland)2025

Anticonvulsant Effects of Synthetic

Karin Jannet Vera-López, Jorge Alberto Aguilar-Pineda, Rodrigo Martín Moscoso-Palacios, Gonzalo Davila-Del-Carpio, José Luis Manrique-Murillo, Badhin Gómez, Minerva González-Melchor, Rita Nieto-Montesinos

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karin Jannet Vera-LópezEscuela Profesional de Farmacía y Bioquímica, Universidad Católica de Santa María, Urb. San José s/n, Umacollo, Arequipa 04000, Peru.ORCID 0000-0002-7908-8230
Jorge Alberto Aguilar-PinedaInstituto de Física "Luis Rivera Terrazas", Benemérita Universidad Autónoma de Puebla, Av. San Claudio, Cd. Universitaria, Apdo. Postal J-48, Puebla 72570, Mexico.ORCID 0000-0003-2921-5681
Rodrigo Martín Moscoso-PalaciosEscuela Profesional de Farmacía y Bioquímica, Universidad Católica de Santa María, Urb. San José s/n, Umacollo, Arequipa 04000, Peru.ORCID 0009-0004-0915-2358
Gonzalo Davila-Del-CarpioEscuela Profesional de Farmacía y Bioquímica, Universidad Católica de Santa María, Urb. San José s/n, Umacollo, Arequipa 04000, Peru.ORCID 0000-0001-7842-9286
José Luis Manrique-MurilloCentro de Investigación en Ingeniería Molecular-CIIM, Universidad Católica de Santa María, Urb. San José s/n-Umacollo, Arequipa 04000, Peru.ORCID 0000-0003-0976-3349
Badhin GómezEscuela Profesional de Farmacía y Bioquímica, Universidad Católica de Santa María, Urb. San José s/n, Umacollo, Arequipa 04000, Peru.ORCID 0000-0001-6539-1207
Minerva González-MelchorInstituto de Física "Luis Rivera Terrazas", Benemérita Universidad Autónoma de Puebla, Av. San Claudio, Cd. Universitaria, Apdo. Postal J-48, Puebla 72570, Mexico.ORCID 0000-0002-8975-3740
Rita Nieto-MontesinosEscuela Profesional de Farmacía y Bioquímica, Universidad Católica de Santa María, Urb. San José s/n, Umacollo, Arequipa 04000, Peru.ORCID 0000-0002-5671-4593

Funding

Vicerrectorado de Investigación de Universidad Católica de Santa María 27038-R-2019
6 · The paper itself

Abstract

Epilepsy is a chronic neurological disorder that affects nearly 50 million people worldwide. Experimental evidence suggests that epileptic neurons are linked to the endocannabinoid system and that inhibition of the FAAH enzyme could have neuroprotective effects by increasing the levels of endogenous endocannabinoid anandamide. In this context, the use of macamides as therapeutic agents in neurological diseases has increased in recent years. With a similar structure to anandamide, several theories point to the FAAH-macamide interaction as a possible cause of FAAH enzymatic inhibition. In this work, we used in silico and in vivo techniques to analyze the potential therapeutic effect of three synthetic macamides in the treatment of epilepsy:

Indexed as

AmidesAnticonvulsantsEpilepsyOleic AcidsAmidohydrolasesAnimalsComputer SimulationFatty Acid Amide HydrolasesMaleMolecular Docking SimulationMolecular Dynamics SimulationPolyunsaturated AlkamidesRatsSeizuresAmidesAmidohydrolasesAnticonvulsantsFatty Acid Amide HydrolasesOleic AcidsoleylamidePolyunsaturated Alkamidesepilepsymacamidesmolecular dynamicsneuroprotective effectsrFAAH

Identifiers

PMID39860203
PMCPMC11767965

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.