Evidence map›Paper›PMID 39860198›Full record

ReviewMolecules (Basel, Switzerland)2025

Fibroin-Hybrid Systems: Current Advances in Biomedical Applications.

Matheus Valentin Maia, Eryvaldo Sócrates Tabosa do Egito, Anne Sapin-Minet, Daniel Bragança Viana, Ashok Kakkar, Daniel Crístian Ferreira Soares

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Clinical progress and prospects of biodegradable intestinal stents.American journal of translational research · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matheus Valentin MaiaLaboratório de Bioengenharia, Universidade Federal de Itajubá, Itabira 35903-087, Minas Gerais, Brazil.ORCID 0000-0001-9682-9566
Eryvaldo Sócrates Tabosa do EgitoLaboratório de Sistemas Dispersos LaSiD, Faculdade de Farmácia, Universidade Federal do Rio Grande no Norte, Natal 59012-570, Rio Grande do Norte, Brazil.ORCID 0000-0002-2180-3991
Anne Sapin-MinetFaculté de Pharmacie, Université de Lorraine, CITHEFOR, F-54000 Nancy, France.
Daniel Bragança VianaLaboratório de Bioengenharia, Universidade Federal de Itajubá, Itabira 35903-087, Minas Gerais, Brazil.ORCID 0000-0001-8057-6162
Ashok KakkarDepartment of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, QC H3A 0B8, Canada.
Daniel Crístian Ferreira SoaresLaboratório de Bioengenharia, Universidade Federal de Itajubá, Itabira 35903-087, Minas Gerais, Brazil.ORCID 0000-0002-2204-6881

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 305169/2023-8Fundo de Amparo à Pesquisa do Estado de Minas Gerais - FAPEMIG APQ-02290-23Natural Sciences and Engineering Research Council RGPIN-2023-03565New Frontiers in Research Fund NFRFE-2022-00356
6 · The paper itself

Abstract

Fibroin, a protein extracted from silk, offers advantageous properties such as non-immunogenicity, biocompatibility, and ease of surface modification, which have been widely utilized for a variety of biomedical applications. However, in vivo studies have revealed critical challenges, including rapid enzymatic degradation and limited stability. To widen the scope of this natural biomacromolecule, the grafting of polymers onto the protein surface has been advanced as a platform to enhance protein stability and develop smart conjugates. This review article brings into focus applications of fibroin-hybrid systems prepared using chemical modification of the protein with polymers and inorganic compounds. A selection of recent preclinical evaluations of these hybrids is included to highlight the significance of this approach.

Indexed as

FibroinsAnimalsBiocompatible MaterialsHumansPolymersBiocompatible MaterialsFibroinsPolymersbiomedical applicationschemical modificationhybrid systemsilk fibroinsurface-grafting polymerization

Identifiers

PMID39860198
PMCPMC11767523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.