Evidence map›Paper›PMID 39860187›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis and Biological Evaluation of New

Lidia Prieto, Daniel Gaviña, Marcos Escolano, María Cánovas-Belchí, María Sánchez-Roselló, Carlos Del Pozo, Eva Falomir, Santiago Díaz-Oltra

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Vascular Disruption Therapy as a New Strategy for Cancer Treatment.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lidia PrietoDepartment of Organic Chemistry, University of Valencia, E-46100 Burjassot, Spain.
Daniel GaviñaDepartment of Organic Chemistry, University of Valencia, E-46100 Burjassot, Spain.
Marcos EscolanoDepartment of Organic Chemistry, University of Valencia, E-46100 Burjassot, Spain.ORCID 0000-0003-1804-9542
María Cánovas-BelchíDepartment of Organic Chemistry, University of Valencia, E-46100 Burjassot, Spain.
María Sánchez-RosellóDepartment of Organic Chemistry, University of Valencia, E-46100 Burjassot, Spain.
Carlos Del PozoDepartment of Organic Chemistry, University of Valencia, E-46100 Burjassot, Spain.
Eva FalomirDepartment of Organic and Inorganic Chemistry, University Jaume I, E-12071 Castellón, Spain.ORCID 0000-0003-0329-6313
Santiago Díaz-OltraDepartment of Organic Chemistry, University of Valencia, E-46100 Burjassot, Spain.ORCID 0000-0002-4771-5885

Funding

Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital CIAICO/2022/216Ministerio de Ciencia, Innovación y Universidades FPU18/02750Ministerio de Ciencia, Innovación y Universidades MS21-140Ministerio de Ciencia, Innovación y Universidades PID2023-152270NB-I00
6 · The paper itself

Abstract

The natural products combretastatins A-1 and A-4 are potent antimitotic and vascular-disrupting agents through their binding at the colchicine site in tubulin. However, these compounds suffer from a low water solubility and a tendency to isomerize to the inactive

Indexed as

Antineoplastic AgentsBibenzylsStilbenesTriazolesA549 CellsCell Line, TumorCell ProliferationCell SurvivalDrug Screening Assays, AntitumorHEK293 CellsHT29 CellsHumansMolecular StructureStructure-Activity RelationshipTubulinAntineoplastic AgentsBibenzylsfosbretabulinStilbenesTriazolesTubulinantimitoticscancercombretastatin A-4cytotoxicitytriazolestubulin

Identifiers

PMID39860187
PMCPMC11767582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.