Evidence map›Paper›PMID 39860186›Full record

ArticleMolecules (Basel, Switzerland)2025

Resveratrol-Based Carbamates as Selective Butyrylcholinesterase Inhibitors: Design, Synthesis, Computational Study and Biometal Complexation Capability.

Maja Sviben, Ilijana Odak, Danijela Barić, Milena Mlakić, Ottó Horváth, Lajos Fodor, Sunčica Roca, Ivana Šagud, Irena Škorić

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maja SvibenDepartment of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, HR-10 000 Zagreb, Croatia.
Ilijana OdakDepartment of Chemistry, Faculty of Science and Education, University of Mostar, Matice Hrvatske bb, 88 000 Mostar, Bosnia and Herzegovina.ORCID 0000-0002-6883-8470
Danijela BarićGroup for Computational Life Sciences, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička Cesta 54, HR-10 000 Zagreb, Croatia.ORCID 0000-0002-5614-5167
Milena MlakićDepartment of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, HR-10 000 Zagreb, Croatia.ORCID 0000-0001-8371-4946
Ottó HorváthEnvironmental and Inorganic Photochemistry Research Group, Center for Natural Sciences, Faculty of Engineering, University of Pannonia, P.O. Box 158, H-8201 Veszprém, Hungary.ORCID 0000-0002-5325-8430
Lajos FodorEnvironmental and Inorganic Photochemistry Research Group, Center for Natural Sciences, Faculty of Engineering, University of Pannonia, P.O. Box 158, H-8201 Veszprém, Hungary.ORCID 0000-0002-1215-6980
Sunčica RocaNMR Center, Rudjer Bošković Institute, Bijenička Cesta 54, HR-10 000 Zagreb, Croatia.ORCID 0000-0001-9562-6820
Ivana ŠagudCroatian Agency for Medicinal Products and Medical Devices, Ksaverska Cesta 4, HR-10 000 Zagreb, Croatia.ORCID 0000-0003-4410-3602
Irena ŠkorićDepartment of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, HR-10 000 Zagreb, Croatia.ORCID 0000-0002-1563-7261

Funding

Croatian-Hungarian bilateral project under the title Synthesis, Characterization and Photocatalytic Transformations of Resveratrol An-alogues with Potential Biological Activity 2023-1.2.4-TÉT-2023-00021Ministry for Innovation and Technology of Hungary from the National Research, Development and Innovation Fund TKP2021-NKTA-21
6 · The paper itself

Abstract

Considering our previous experience in the design of new cholinesterase inhibitors, especially resveratrol analogs, in this research, the basic stilbene skeleton was used as a structural unit for new carbamates designed as potentially highly selective butyrylcholinesterase (BChE) inhibitors with excellent absorption, distribution, metabolism, excretion and toxicity ADMET properties. The inhibitory activity of newly prepared carbamates

Indexed as

ButyrylcholinesteraseCarbamatesCholinesterase InhibitorsResveratrolAcetylcholinesteraseDrug DesignHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCarbamatesCholinesterase InhibitorsResveratrolADMETbiometal complexationbutyrylcholinesterase inhibitioncarbamatesdockingmolecular dynamicssynthesis

Identifiers

PMID39860186
PMCPMC11767309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.