Evidence map›Paper›PMID 39860164›Full record

ArticleMolecules (Basel, Switzerland)2025

Insights into the Mode of Action of Novel Morpholinated Curcumin Derivatives Exhibiting Potent Antitumor Activity in Bladder Cancer Cells In Vitro.

Paulina Kobylka, Pawel Bakun, Joanna Kuzminska, Tomasz Goslinski, Marek Murias, Malgorzata Kucinska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paulina KobylkaDepartment of Toxicology, Poznan University of Medical Sciences, Rokietnicka 3 Street, 60-806 Poznan, Poland.ORCID 0000-0003-3105-8144
Pawel BakunDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka 3 Street, 60-806 Poznan, Poland.ORCID 0000-0002-0831-2856
Joanna KuzminskaDepartment of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3 Street, 60-806 Poznan, Poland.ORCID 0000-0002-8514-5238
Tomasz GoslinskiDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka 3 Street, 60-806 Poznan, Poland.ORCID 0000-0001-5705-5414
Marek MuriasDepartment of Toxicology, Poznan University of Medical Sciences, Rokietnicka 3 Street, 60-806 Poznan, Poland.ORCID 0000-0002-2903-4912
Malgorzata KucinskaDepartment of Toxicology, Poznan University of Medical Sciences, Rokietnicka 3 Street, 60-806 Poznan, Poland.ORCID 0000-0002-3606-3623

Funding

National Science Center 2019/35/B/NZ7/01165
6 · The paper itself

Abstract

Although curcumin is a well-known natural polyphenol with many biological activities, its clinical application has been limited by low aqueous solubility and stability. Therefore, curcumin derivatives have been proposed to overcome these limitations and increase anticancer activity. This study tested curcumin derivatives with modified feruloyl moieties (

Indexed as

Antineoplastic AgentsCurcuminUrinary Bladder NeoplasmsApoptosisCell CycleCell Line, TumorCell ProliferationHumansMembrane Potential, MitochondrialProto-Oncogene Proteins c-aktAntineoplastic AgentsCurcuminProto-Oncogene Proteins c-aktapoptosisbladder cancercancer researchcurcumincurcumin derivativeshypoxia

Identifiers

PMID39860164
PMCPMC11767817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.