Evidence map›Paper›PMID 39860162›Full record

ArticleMolecules (Basel, Switzerland)2025

Anti-Neuroinflammatory Effects of Prenylated Indole Alkaloids from the Antarctic Fungus

Zhiming Liu, Chi-Su Yoon, Thao Quyen Cao, Hwan Lee, Il-Chan Kim, Joung Han Yim, Jae Hak Sohn, Dong-Sung Lee, Hyuncheol Oh

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiming LiuKey Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, School of Pharmacy, Yantai University, Yantai 264005, China.
Chi-Su YoonInstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea.
Thao Quyen CaoInstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea.ORCID 0000-0002-9704-1807
Hwan LeeResearch Institute of Pharmaceutical Sciences (RIPS), College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Republic of Korea.ORCID 0000-0001-5015-5949
Il-Chan KimDivision of Life Sciences, Korea Polar Research Institute, Incheon 21990, Republic of Korea.ORCID 0000-0002-5776-7582
Joung Han YimDivision of Life Sciences, Korea Polar Research Institute, Incheon 21990, Republic of Korea.ORCID 0000-0003-4415-1778
Jae Hak SohnCollege of Medical and Life Sciences, Silla University, Busan 46958, Republic of Korea.
Dong-Sung LeeResearch Institute of Pharmaceutical Sciences (RIPS), College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Republic of Korea.ORCID 0000-0002-9234-7567
Hyuncheol OhInstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea.

Funding

This research was supported by a Korea Polar Research Institute (KOPRI) grant funded by the Ministry of Oceans and Fisheries, Korea. PE24160 and RS-2021-KS211513
6 · The paper itself

Abstract

Inflammation has always been considered a trigger or consequence of neurodegenerative diseases, and the inhibition of inflammation in the central nervous system can effectively protect nerve cells. Several studies have indicated that various natural products inhibit neuroinflammation. Among these, Antarctic fungal metabolites have pharmacological activities and a developmental value. Therefore, this study aimed to evaluate the anti-neuroinflammatory activity of an Antarctic fungus belonging to

Indexed as

Anti-Inflammatory AgentsAspergillusIndole AlkaloidsAnimalsAntarctic RegionsLipopolysaccharidesMacrophagesMiceMicrogliaMolecular Docking SimulationNF-kappa BPrenylationRAW 264.7 CellsSignal TransductionAnti-Inflammatory AgentsIndole AlkaloidsLipopolysaccharidesNF-kappa BAntarctic fungianti-inflammationmolecular dockingNF-κBprenylated indole alkaloid

Identifiers

PMID39860162
PMCPMC11767326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.