Stereoelectronic Effect of Protecting Groups on the Stability of Galactosyl Donor Intermediates.

Ryan W Kwok, Ryan Rutkoski, Pavel Nagorny, Mateusz Marianski

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryan W KwokDepartment of Chemistry, Hunter College, The City University of New York, 695 Park Ave., New York, NY 10065, USA.ORCID 0000-0001-7245-9142

Ryan RutkoskiDepartment of Chemistry, University of Michigan, 930 University Ave., Ann Arbor, MI 48109, USA.

Pavel NagornyDepartment of Chemistry, University of Michigan, 930 University Ave., Ann Arbor, MI 48109, USA.ORCID 0000-0002-7043-984X

Mateusz MarianskiDepartment of Chemistry, Hunter College, The City University of New York, 695 Park Ave., New York, NY 10065, USA.ORCID 0000-0002-6566-9931

Funding

New Methods and Strategies for the Synthesis and Selective Derivatization of Natural ProductsR35GM136341 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pavel Nagorny · 2020 to 2026

$2.6M

NIGMS NIH HHS R35 GM136341NIH HHS GM136341NSF CHE-2303044NSF NRT-2151945

6 · The paper itself

Abstract

Using methods of DFT, we investigated the effect of electron withdrawing and electron donating groups on the relative stability of tentative glycosyl donor reaction intermediates. The calculation shows that by changing the stereoelectronic properties of the protecting group, we can influence the stability of the dioxolenium type of intermediates by up to 10 kcal mol

Indexed as

DFTglycosylation mechanismremote participation

Identifiers

PMID39860088

DOI10.3390/molecules30020218

PMCPMC11767833

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.