Evidence map›Paper›PMID 39860009›Full record

ArticleLife (Basel, Switzerland)2025

Regulation of LPS-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells via TLR4-Mediated NF-κB and MAPK Signaling Pathways by Lactoferrin.

Kai Zhang, Ruizhen Zhang, Yuanyuan Zhang, Min Zhang, Hong Su, Feifei Zhao, Daqing Wang, Guifang Cao, Yong Zhang

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Assessing theAntioxidants (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kai ZhangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010010, China.ORCID 0000-0001-5235-4562
Ruizhen ZhangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010010, China.
Yuanyuan ZhangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010010, China.ORCID 0009-0003-3791-8296
Min ZhangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010010, China.
Hong SuCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010010, China.ORCID 0000-0002-8656-8259
Feifei ZhaoCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010010, China.
Daqing WangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010010, China.
Guifang CaoCollege of Life Sciences, Inner Mongolia University, Hohhot 010011, China.
Yong ZhangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010010, China.

Funding

Inner Mongolia Autonomous Region"Jiebangguashuai" project of China 2022JBGS0021The National Dairy Technology Innovation Center project of China 2023-JSGG-2
6 · The paper itself

Abstract

Lactoferrin (LF), a member of the transferrin family, is widely present in mammalian milk and other secretions, exhibiting anti-inflammatory, antibacterial, and anti-infective properties. Although the biological functions of LF have been extensively studied, there are few reports on its effects and molecular mechanisms concerning bovine mastitis caused by bacterial infection. This study used bovine mammary epithelial cells (BMECs) cultured in vitro as the research model. An inflammatory injury model was established by stimulating BMECs with LPS to investigate whether LF at different concentrations (10, 50, 100, and 200 μg·mL

Indexed as

bovine mammary epithelial cellslactoferrinlipopolysaccharidesignal path

Identifiers

PMID39860009
PMCPMC11767191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.