Evidence map›Paper›PMID 39859967›Full record

ArticleLife (Basel, Switzerland)2024

Associations of Voice Metrics with Postural Function in Parkinson's Disease.

Anna Carolyna Gianlorenço, Valton Costa, Walter Fabris-Moraes, Paulo Eduardo Portes Teixeira, Paola Gonzalez, Kevin Pacheco-Barrios, Ciro Ramos-Estebanez, Arianna Di Stadio, Mirret M El-Hagrassy, Deniz Durok Camsari and 3 more

Abstract read
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In one paragraph

Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna Carolyna GianlorençoNeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA.ORCID 0000-0002-7334-3835
Valton CostaNeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA.ORCID 0000-0002-2356-7523
Walter Fabris-MoraesNeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA.
Paulo Eduardo Portes TeixeiraHighland Instruments, Inc., Cambridge, MA 02238, USA.
Paola GonzalezNeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA.
Kevin Pacheco-BarriosNeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA.
Ciro Ramos-EstebanezDepartment of Neurology and Rehabilitation, University of Illinois at Chicago, 912 S Wood St., MC 796, Chicago, IL 60612, USA.ORCID 0000-0001-6737-5374
Arianna Di StadioOtolaryngology Unit, GF Ingrassia Department, University of Catania, 95121 Catania, Italy.ORCID 0000-0001-5510-3814
Mirret M El-HagrassyNeurology Department, UMass Memorial, UMass Chan Medical School, Suite #301, 67 Belmont St., Worcester, MA 01605, USA.
Deniz Durok CamsariMayo Clinic, 200 1st St SW, Rochester, MN 55901, USA.
Tim WagnerHighland Instruments, Inc., Cambridge, MA 02238, USA.
Laura DipietroHighland Instruments, Inc., Cambridge, MA 02238, USA.
Felipe FregniNeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA.ORCID 0000-0002-1703-7526

Funding

ESStim for the Treatment of Postural Instability in Patients with Parkinson's Disease - Phase IIBR44NS110237 · NINDS · HIGHLAND INSTRUMENTS, INC. · PI Laura Dipietro, Timothy Andrew Wagner · 2019 to 2026
$3.2M
Noninvasive Neural Stimulation TechnologyR44NS080632 · NINDS · HIGHLAND INSTRUMENTS, INC. · PI WAGNER, TIMOTHY ANDREW · 2012 to 2015
$3.0M
Stroke Assessment SuiteR43NS113737 · NINDS · HIGHLAND INSTRUMENTS, INC. · PI DIPIETRO, LAURA, WAGNER, TIMOTHY ANDREW · 2019 to 2019
$224k
NIH HHS R43NS113737, R44NS080632 and R44NS110237NINDS NIH HHS R43 NS113737NINDS NIH HHS R44 NS080632NINDS NIH HHS R44 NS110237
6 · The paper itself

Abstract

backgroundThis study aimed to explore the potential associations between voice metrics of patients with PD and their motor symptoms.

methodsMotor and vocal data including the Unified Parkinson's Disease Rating Scale part III (UPDRS-III), Harmonic-Noise Ratio (HNR), jitter, shimmer, and smoothed cepstral peak prominence (CPPS) were analyzed through exploratory correlations followed by univariate linear regression analyses. We employed these four voice metrics as independent variables and the total and sub-scores of the UPDRS-III as dependent variables.

resultsThirteen subjects were included, 76% males and 24% females, with a mean age of 62.9 ± 10.1 years, and a median Hoehn and Yahr stage of 2.3 ± 0.7. The regression analysis showed that CPPS is associated with posture (UPDRS-III posture scores: β = -0.196; F = 10.0;

conclusionThese findings highlight the potential role of CPPS as a predictor of postural impairments secondary to PD, emphasizing the need for further investigation.

Indexed as

acoustic analysisParkinson’s diseasepostural stabilityposturesmoothed cepstral peak prominencevoice disorder

Identifiers

PMID39859967
PMCPMC11766558

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.