Evidence map›Paper›PMID 39859538›Full record

ArticleInternational journal of molecular sciences2025

Biomarkers of Intrathecal Synthesis May Be Associated with Cognitive Impairment at MS Diagnosis.

Eleonora Virgilio, Valentina Ciampana, Chiara Puricelli, Paola Naldi, Angelo Bianchi, Umberto Dianzani, Domizia Vecchio, Cristoforo Comi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eleonora VirgilioNeurology Unit, Department of Clinical and Biological Sciences, University Hospital San Luigi Gonzaga, University of Turin, 10043 Turin, Italy.ORCID 0000-0002-0045-3806
Valentina CiampanaNeurology Unit, Department of Translational Medicine, University Hospital Maggiore della Carità di Novara, University of Piemonte Orientale, 28100 Novara, Italy.
Chiara PuricelliClinical Biochemistry, University Hospital Maggiore della Carità di Novara, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-0416-6687
Paola NaldiNeurology Unit, Department of Translational Medicine, University Hospital Maggiore della Carità di Novara, University of Piemonte Orientale, 28100 Novara, Italy.
Angelo BianchiNeurology Unit, Department of Translational Medicine, University Hospital Maggiore della Carità di Novara, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0001-6195-7357
Umberto DianzaniInterdisciplinary Research Center of Autoimmune Diseases (IRCAD), Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.
Domizia VecchioInterdisciplinary Research Center of Autoimmune Diseases (IRCAD), Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0001-5920-9210
Cristoforo ComiInterdisciplinary Research Center of Autoimmune Diseases (IRCAD), Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-6862-9468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathophysiology of cognitive impairment (CI) in multiple sclerosis (MS) remains unclear. Meningeal B cell aggregates may contribute to cortical grey matter pathology. Cerebrospinal fluid (CSF), kappa free light chains (KFLC), and KFLCs-Index (kappa-Index) are reliable quantitative markers of intrathecal synthesis, but few data have been presented exploring the association with CI, and no data are present for lambda FLC (LFLC) in MS. We evaluated cognition using the Brief International Cognitive Assessment for MS (BICAMS) battery and collected serum and CSF at diagnosis in newly diagnosed drug-naïve MS patients. We observed that patients with impaired verbal memory and overall CI showed increased CSF KFLCs (respectively

Indexed as

BiomarkersCognitive DysfunctionMultiple SclerosisAdultFemaleHumansImmunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsMaleMiddle AgedBiomarkersImmunoglobulin kappa-ChainsImmunoglobulin lambda-Chainsbiomarkercognitionkappa free light chainkappa indexlambda indexmultiple sclerosisoligoclonal band

Identifiers

PMID39859538
PMCPMC11765557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.