Evidence map›Paper›PMID 39859514›Full record

ArticleInternational journal of molecular sciences2025

Effects of Aging on Intramuscular Collagen-Related Factors After Injury to Mouse Tibialis Anterior Muscle.

Yuji Kanazawa, Tatsuo Takahashi, Takao Inoue, Mamoru Nagano, Satoshi Koinuma, Haruki Eiyo, Yuma Tamura, Ryo Miyachi, Naoya Iida, Kenichiro Miyahara and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuji KanazawaDepartment of Physical Therapy, Hokuriku University, Kanazawa 920-1180, Japan.ORCID 0000-0002-2838-6297
Tatsuo TakahashiWell-Being Research Team, Hokuriku University, Kanazawa 920-1180, Japan.
Takao InoueDepartment of Pathology, Faculty of Medicine, Kindai University, Osakasayama 589-8511, Japan.
Mamoru NaganoDepartment of Anatomy and Neurobiology, Faculty of Medicine, Kindai University, Osakasayama 589-8511, Japan.
Satoshi KoinumaDepartment of Anatomy and Neurobiology, Faculty of Medicine, Kindai University, Osakasayama 589-8511, Japan.
Haruki EiyoDepartment of Rehabilitation, Dokkyo Medical University Nikko Medical Center, Nikko 321-1298, Japan.
Yuma TamuraDepartment of Rehabilitation, Dokkyo Medical University Nikko Medical Center, Nikko 321-1298, Japan.ORCID 0000-0002-6439-3515
Ryo MiyachiDepartment of Physical Therapy, Hokuriku University, Kanazawa 920-1180, Japan.ORCID 0000-0002-4890-4223
Naoya IidaDepartment of Anatomy and Neurobiology, Faculty of Medicine, Kindai University, Osakasayama 589-8511, Japan.ORCID 0000-0002-9653-6875
Kenichiro MiyaharaDepartment of Physical Therapy, Hokuriku University, Kanazawa 920-1180, Japan.ORCID 0000-0003-0288-0913
Yasufumi ShigeyoshiDepartment of Anatomy and Neurobiology, Faculty of Medicine, Kindai University, Osakasayama 589-8511, Japan.

Funding

Hokuriku University Special Research GrantJapan Society for the Promotion of Science (JSPS) 22K11300, 22K11327
6 · The paper itself

Abstract

Collagen I is the most abundant type of intramuscular collagen. Lysyl oxidase promotes collagen cross-link formation, which helps stabilize the extracellular matrix. Furthermore, matrix metalloproteinases, responsible for collagen degradation, maintain typical muscle structure and function through remodeling. Although it is well known that aging leads to delayed recovery of muscle fibers, the impact of aging on the remodeling of intramuscular collagen is not well understood. In this study, we investigated the impact of aging on collagen remodeling during muscle injury recovery using young and old mouse models. Muscle injury was induced in the right tibialis anterior (TA) muscle of male C57BL/6J mice [aged 21 weeks (young) and 92 weeks (old)] using intramuscular cardiotoxin injection, with the left TA serving as a sham with saline injection. Following a one-week recovery period, aging was found to delay the recovery of the fiber cross-sectional area. The intensity and area of immunoreactivity for collagen I were significantly increased in old mice compared to young mice post-injury. Additionally,

Indexed as

AgingCollagenCollagen Type IMuscle, SkeletalAnimalsExtracellular MatrixMaleMatrix Metalloproteinase 9MiceMice, Inbred C57BLProtein-Lysine 6-OxidaseCollagenCollagen Type IMatrix Metalloproteinase 9Mmp9 protein, mouseProtein-Lysine 6-Oxidaseagingextracellular matrixlysyl oxidasematrix metalloproteinasemuscle injury

Identifiers

PMID39859514
PMCPMC11766099

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.