Evidence map›Paper›PMID 39859463›Full record

ArticleInternational journal of molecular sciences2025

Exploring the Link Between Renal Function Fluctuations Within the Physiological Range and Serum/CSF Levels of NfL, GFAP, tTAU, and UCHL1.

Kimberly Koerbel, Yavor Yalachkov, Tabea Rotter, Martin A Schaller-Paule, Jan Hendrik Schaefer, Lucie Friedauer, Jasmin Jakob, Falk Steffen, Stefan Bittner, Christian Foerch and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Interpreting p-tau217 on the ward: frailty and plasma biomarkers in acutely admitted older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kimberly KoerbelDepartment of Neurology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-7081-3096
Yavor YalachkovDepartment of Neurology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-0805-771X
Tabea RotterDepartment of Neurology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.
Martin A Schaller-PauleDepartment of Neurology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.
Jan Hendrik SchaeferDepartment of Neurology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.
Lucie FriedauerDepartment of Neurology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.
Jasmin JakobDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (Rmn2), Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Falk SteffenDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (Rmn2), Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.ORCID 0000-0003-3708-8600
Stefan BittnerDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (Rmn2), Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.ORCID 0000-0003-2179-3655
Christian FoerchDepartment of Neurology, Klinikum Ludwigsburg, 71640 Ludwigsburg, Germany.
Michelle MaiwormDepartment of Neurology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.

Funding

Deutsche Forschungsgemeinschaft project number 511312822Fokus Förderprogramm GRADEHeinrich und Erna Schaufler StiftungHermann and Lilly Schilling Foundation.Sanofi Genzyme GZ-2016-11612
6 · The paper itself

Abstract

Impaired renal function can influence biomarker levels through mechanisms involving blood-brain barrier integrity and clearance pathways; however, the impact of variations within normal renal function remains unclear. The main aim of this study was to determine whether adjustment for the specific level of renal function is necessary when renal function remains within physiological levels. We studied n = 183 patients (NID n = 122; other neurological diseases n = 39; somatoform controls n = 22) who underwent lumbar puncture at University Hospital Frankfurt. Serum and cerebrospinal fluid (CSF) levels of neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tau protein (tTAU), and ubiquitin C-terminal hydrolase-L1 (UCHL1) were measured using the single molecule array (SIMOA) technique. Estimated glomerular filtration rate (eGFR) correlated negatively with CSF GFAP (r = -0.217,

Indexed as

Glial Fibrillary Acidic ProteinKidneyNeurofilament Proteinstau ProteinsUbiquitin ThiolesteraseAdultAgedBiomarkersFemaleGlomerular Filtration RateHumansMaleMiddle AgedBiomarkersGFAP protein, humanGlial Fibrillary Acidic ProteinMAPT protein, humanneurofilament protein LNeurofilament Proteinstau ProteinsUbiquitin ThiolesteraseUCHL1 protein, humanbiomarkerscerebrospinal fluidkidney functionNfLserum

Identifiers

PMID39859463
PMCPMC11765624

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.