ReviewInternational journal of molecular sciences2025
Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Transposon-mediated structural haplotypes at CsMYB60 are associated with peel coloration in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Article
- Integrated Transcriptomic Profiling Reveals Distinct and Overlapping Transcriptional Responses and Regulatory Pathways Mediated by Salicylic Acid, Jasmonic Acid, and Abscisic Acid in Lotus (International journal of molecular sciences · 2026Article
- Genome-wide analysis and expression profiling of the phenylalanine ammonia-lyase gene family in Chrysanthemum morifolium.BMC plant biology · 2026Article
- Transcription factor MdMYB6L represses anthocyanin biosynthesis of apple skin at low-altitude regions.Plant cell reports · 2026Article
- Article
- The transcription factorHorticulture research · 2026Article
- SmYABBY1, a Light-Inducible Transcription Factor, Positively Regulates Anthocyanin Biosynthesis in Eggplant (International journal of molecular sciences · 2026Article
- Transcriptomics and functional characterization identify CYP73A16 as a key regulator of flavonoid biosynthesis in mulberry leaves.BMC plant biology · 2026Article
- Integrated Metabolomics and Transcriptomics Reveal the Influence of Natural and Cultivation-Managed Habitats on Metabolic Divergence and Flavonoid Enrichment inMetabolites · 2026Article
- Skin wound healing effects of Pectinodesmus javanensis extract through activation of TGF-β/SMAD signaling pathway.Molecular biology reports · 2026Article
- Integrative Analysis of Transcriptome and Metabolome Reveals Regulatory Networks Associated with Flavonoids in Leaves ofPlants (Basel, Switzerland) · 2026Article
- Integrated transcriptomic and metabolomic analysis reveals the regulatory role of lignin biosynthesis in raspberry (Rubus niveus) prickle development.BMC plant biology · 2026Article
- The RcMYB308-RcEGL1 module regulates cyanidin accumulation by targeting the RcF3'H promoter in pink roses.BMC plant biology · 2026Article
- Integrative metabolomic and transcriptomic analyses reveal the regulatory mechanisms underlying the biosynthesis of flavonoid and terpenoid metabolites in different tissues ofFrontiers in plant science · 2026Article
- Integrative transcriptomic and metabolomic analysis reveals the molecular basis of leaf variegation inFrontiers in plant science · 2026Article
- Metabolomics and Transcriptomics Analyses Uncover the Potential of Flavonoids in Response to Saline-Alkali Stress inBiology · 2025Article
- Integrative metabolomic and transcriptomic analyses reveal flavonoid biosynthesis pathway in Eupatorium lindleyanum.Scientific reports · 2025Article
- Multifaceted roles and regulatory mechanisms of MYB transcription factors in plant development, secondary metabolism, and stress adaptation: current insights and future prospects.GM crops & food · 2025Review
- Integrated transcriptomic and metabolomic analysis unveils heat-tolerance-associated flavonoid metabolites and genes in the rice rel1-D mutant.BMC genomics · 2025Article
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4 authors.
Funding
Abstract
Flavonoids are a large group of secondary metabolites, which are responsible for pigmentation, signaling, protection from unfavorable environmental conditions, and other important functions, as well as providing numerous benefits for human health. Various stages of flavonoid biosynthesis are subject to complex regulation by three groups of transcription regulators-MYC-like bHLH, R2R3-MYB and WDR which form the MBW regulatory complex. We attempt to cover the main aspects of this intriguing regulatory system in plants, as well as to summarize information on their distinctive features in cereals. Published data revealed the following perspectives for further research: (1) In cereals, a large number of paralogs of MYC and MYB transcription factors are present, and their diversification has led to spatial and biochemical specialization, providing an opportunity to fine-tune the distribution and composition of flavonoid compounds; (2) Regulatory systems formed by MBW proteins in cereals possess distinctive features that are not yet fully understood and require further investigation; (3) Non-classical MB-EMSY-like complexes, WDR-independent MB complexes, and solely acting R2R3-MYB transcription factors are of particular interest for studying unique regulatory mechanisms in plants. More comprehensive understanding of flavonoid biosynthesis regulation will allow us to develop cereal varieties with the required flavonoid content and spatial distribution.
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