A Lateral Line Specific Mucin Involved in Cupula Growth and Vibration Detection in Zebrafish.

Ziyue Ma, Yixuan Tian, Yingying Wang, Chenghao Wang, Jian Wang, Chunxin Fan

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ziyue MaInstitute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai 201306, China.

Yixuan TianInstitute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai 201306, China.

Yingying WangInstitute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai 201306, China.

Chenghao WangInstitute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai 201306, China.

Jian WangInstitute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0001-8699-4998

Chunxin FanInstitute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0002-8673-4595

Funding

National Natural Science Foundation of China 31702329National Natural Science Foundation of China 31772406

6 · The paper itself

Abstract

The lateral line system in fish is crucial for detecting water flow, which facilitates various behaviors such as prey detection, predator avoidance, and rheotaxis. The cupula, a gelatinous structure overlaying the hair cells in neuromasts, plays a key role in transmitting mechanical stimuli to hair cells. However, the molecular composition of the cupula matrix remains poorly understood. In this study, we found that Mucin-5AC, a novel family of mucin proteins, composed of 2-27 cysteine-rich domains, presents in cartilaginous and bony fishes. Using in situ hybridization and transgenic reporter assays, we demonstrated that zebrafish

Indexed as

Lateral Line SystemMucin 5ACMucinsVibrationZebrafishZebrafish ProteinsAnimalsAnimals, Genetically ModifiedLarvaMutationMucin 5ACMucinsZebrafish Proteinscupulalateral lineMucin-5ACstartle responsezebrafish

Identifiers

PMID39859421

DOI10.3390/ijms26020708

PMCPMC11765562

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.