Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Beatrix HochreiterClinical Division of General Anaesthesia and Intensive Care Medicine, Department of Anesthesia, Genera Intensive Care and Pain Therapy, Medical University Vienna, 1090 Vienna, Austria.
Eva Hunyadi-GulyasCore Facility Proteomics Research Group, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.ORCID 0000-0003-2089-1499
Zsuzsanna DarulaCore Facility Proteomics Research Group, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.
Oliver DomenigAttoquant Diagnostics, 1110 Vienna, Austria.
Smriti SharmaDivision of Cardiology, Department of Internal Medicine II, Vienna General Hospital, Medical University Vienna, 1090 Vienna, Austria.
Irene M LangDivision of Cardiology, Department of Internal Medicine II, Vienna General Hospital, Medical University Vienna, 1090 Vienna, Austria.ORCID 0000-0003-0485-2692
Attila KissCenter for Biomedical Research and Translational Surgery, Medical University Vienna, 1090 Vienna, Austria.ORCID 0000-0003-4652-1998
Andreas SpittlerCore Facility Flow Cytometry and Department of Surgery, Medical University Vienna, 1090 Vienna, Austria.ORCID 0000-0003-2657-6836
Konrad HoetzeneckerDepartment of Thoracic Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Roman Reindl-SchwaighoferClinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University Vienna, 1090 Vienna, Austria.ORCID 0000-0002-4419-6282
Katharina KrennClinical Division of General Anaesthesia and Intensive Care Medicine, Department of Anesthesia, Genera Intensive Care and Pain Therapy, Medical University Vienna, 1090 Vienna, Austria.ORCID 0000-0002-6950-9361
Roman UllrichClinical Division of General Anaesthesia and Intensive Care Medicine, Department of Anesthesia, Genera Intensive Care and Pain Therapy, Medical University Vienna, 1090 Vienna, Austria.
Regina Grillari-VoglauerEvercyte GmbH, 1110 Vienna, Austria.
Verena TretterClinical Division of General Anaesthesia and Intensive Care Medicine, Department of Anesthesia, Genera Intensive Care and Pain Therapy, Medical University Vienna, 1090 Vienna, Austria.ORCID 0000-0001-5910-3053
Funding
Apeptico R&D GmbH no numberEuropean Union 739593.
6 · The paper itself
Abstract
Drug development for human disease relies on preclinical model systems such as human cell cultures and animal experiments before therapeutic treatments can ultimately be tested on humans in clinical studies. We here describe the generation of a novel human cell line (HLMVEC/SVTERT289) that we generated by transfection of microvascular endothelial cells from healthy donor lung tissue with the catalytic domain of telomerase and the SV40 large T/small t-antigen. These cells exhibited satisfactory growth characteristics and largely maintained their native characteristics, including morphology, cell surface marker expression, angiogenic potential and the protein composition of secreted extracellular vesicles. In order to test their suitability as a disease model, we simulated mechanical stress induced by cyclic stretch as encountered in ventilator-induced lung injury using the FlexCell
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Characterizing SV40-hTERT Immortalized Human Lung Microvascular Endothelial Cells as Model System for Mechanical Stretch-Induced Lung Injury. · full record | OpenQuestion