ArticleInternational journal of molecular sciences2025
Polymorphisms Influence the Expression of the Fas and FasL Genes in COVID-19.
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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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Who cites it
1 citing paper in PubMed.
- BCG Vaccination Modulates Long-Term TNF-α and sCD40L in COVID-19: An Exploratory Longitudinal Study.International journal of general medicine · 2026Article
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Authors and funding
33 authors.
Wandrey Roberto Dos Santos BritoLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0009-0007-5170-7216
William Botelho de BritoLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Fabiane Dos Santos FerreiraLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Emmanuelle Giuliana Mendes SantanaLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Jeferson da Costa LopesLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Ednelza da Silva Graça AmorasLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0001-7079-4844
Sandra Souza LimaLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0001-5137-7770
Erika Ferreira Dos SantosGraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0001-9188-1066
Flávia Póvoa da CostaGraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0002-5667-0754
Kevin Matheus Lima de SargesGraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0003-0776-6212
Marcos Henrique Damasceno CantanhedeGraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0003-2263-8403
Mioni Thieli Figueiredo Magalhães de BritoLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0001-8165-8629
Andréa Luciana Soares da SilvaLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0003-4299-0252
Mauro de Meira LeiteLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0002-3620-3470
Maria de Nazaré do Socorro de Almeida VianaGraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Fabíola Brasil Barbosa RodriguesGraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0002-4294-4099
Rosilene da SilvaGraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0001-8913-2971
Giselle Maria Rachid VianaLaboratory of Basic Research on Malaria, Parasitology Section, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 66093-020, Brazil.
Tânia do Socorro Souza ChavesLaboratory of Basic Research on Malaria, Parasitology Section, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 66093-020, Brazil.
Adriana de Oliveira Lameira VeríssimoBelém Adventist Hospital, Belém 66093-904, Brazil.
Mayara da Silva CarvalhoBelém Adventist Hospital, Belém 66093-904, Brazil.
Daniele Freitas HenriquesArbovirology and Hemorrhagic Fevers Section, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 66093-020, Brazil.
Carla Pinheiro da SilvaArbovirology and Hemorrhagic Fevers Section, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 66093-020, Brazil.
Juliana Abreu Lima NunesLaboratory of Immunology, Section of Virology, Instituto Evandro Chagas, Health and Environment Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 66093-020, Brazil.
Iran Barros CostaLaboratory of Immunology, Section of Virology, Instituto Evandro Chagas, Health and Environment Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 66093-020, Brazil.
Igor Brasil-CostaLaboratory of Immunology, Section of Virology, Instituto Evandro Chagas, Health and Environment Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 66093-020, Brazil.ORCID 0000-0003-2600-4109
Juarez Antônio Simões QuaresmaGraduate Program in Virology, Evandro Chagas Institute, Department of Science, Technology, Innovation and Strategic Health Inputs, Ministry of Health of Brazil, Ananindeua 66093-020, Brazil.ORCID 0000-0002-6267-9966
Izaura Maria Vieira Cayres-VallinotoLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Leonardo Oliveira ReisUroScience, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-590, Brazil.ORCID 0000-0003-2092-414X
Luiz Fábio Magno FalcãoCenter of Biological and Health Sciences, University of the State of Pará, Belém 66087-670, Brazil.ORCID 0000-0001-8391-2694
Eduardo José Melo Dos SantosGraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0001-5134-5648
Antonio Carlos Rosário VallinotoLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0003-1135-6507
Maria Alice Freitas QueirozLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0003-2014-2770
Funding
Amazon Foundation for Studies and Research of Pará (FAPESPA) n° 005/2020Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.506617/2020-00 and 88887.657670/2021-00Institute National Institute of Science and Technology in Emerging and Reemerging Viruses (INCT-VER) n° 406360/2022-7National Council for Scientific and Technological Development n° 304835/2022-6, n° 401235/2020-3; n° 302935/2021-5; n° 303837/2023-3, n° 310135/2022-2Secretariat of Science, Technology and Higher Professional and Technological Education (SECTET) n° 09/2021
Abstract
The apoptotic molecule Fas and its ligand FasL are involved in the process of T-lymphocyte death, which may lead to lymphopenia, a characteristic of severe coronavirus disease 2019 (COVID-19). In this study, we investigated the influence of polymorphisms in the
Indexed as
COVID-19Fas Ligand Proteinfas ReceptorPolymorphism, Single NucleotideAdultAgedCytokinesFemaleGenetic Predisposition to DiseaseGenotypeHumansInterferon-gammaMaleMiddle AgedSARS-CoV-2Severity of Illness IndexCytokinesFASLG protein, humanFas Ligand ProteinFAS protein, humanfas ReceptorInterferon-gammaCOVID-19cytokinesFASFASLgene expressionlong COVIDpolymorphisms
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