Evidence map›Paper›PMID 39859367›Full record

ArticleInternational journal of molecular sciences2025

Irisin and Metastatic Melanoma: Selective Anti-Invasiveness Activity in BRAF Wild-Type Cells.

Simona Serratì, Roberta Zerlotin, Michele Manganelli, Roberta Di Fonte, Manuela Dicarlo, Angela Oranger, Graziana Colaianni, Letizia Porcelli, Amalia Azzariti, Stefania Guida and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Simona SerratìIRCCS Istituto Tumori Giovanni Paolo II, 70124 Bari, Italy.ORCID 0000-0002-4015-5205
Roberta ZerlotinDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
Michele ManganelliDepartment of Translational Biomedicine and Neuroscience, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-8219-0252
Roberta Di FonteIRCCS Istituto Tumori Giovanni Paolo II, 70124 Bari, Italy.ORCID 0000-0002-8541-686X
Manuela DicarloDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
Angela OrangerDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
Graziana ColaianniDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
Letizia PorcelliIRCCS Istituto Tumori Giovanni Paolo II, 70124 Bari, Italy.
Amalia AzzaritiIRCCS Istituto Tumori Giovanni Paolo II, 70124 Bari, Italy.ORCID 0000-0002-6149-5049
Stefania GuidaSchool of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0002-8221-6694
Maria GranoDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-7121-5899
Silvia Concetta ColucciDepartment of Translational Biomedicine and Neuroscience, University of Bari, 70124 Bari, Italy.
Gabriella GuidaDepartment of Translational Biomedicine and Neuroscience, University of Bari, 70124 Bari, Italy.ORCID 0000-0003-2345-2838

Funding

C.I.R.E.M.I.C. (Research Center of Excellence for Neurodegenerative Diseases and Brain Aging) - University of Bari "Aldo Moro" - Investment PE8-Project Age-It: "Ageing Well in an Ageing Society" (CUPB83C22004800006Regione Puglia and CNR for Tecnopolo per la Medicina di Precisione. D.G.R. n. 2117 of 21.11.2018 CUPB84I18000540002
6 · The paper itself

Abstract

Irisin is a newly discovered 12 kDa messenger protein involved in energy metabolism. Irisin affects signaling pathways in several types of cancer; however, the role of irisin in metastatic melanoma (MM) has not been described yet. We explored the biological effects of irisin in in vitro models of MM cells (HBL

Indexed as

FibronectinsMelanomaProto-Oncogene Proteins B-rafCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMatrix Metalloproteinase 2Matrix Metalloproteinase 9Neoplasm InvasivenessNeoplasm MetastasisBRAF protein, humanFibronectinsFNDC5 protein, humanMatrix Metalloproteinase 2Matrix Metalloproteinase 9Proto-Oncogene Proteins B-rafBRAFfibrinolytic systemirisinmelanomaMMPsmyokine

Identifiers

PMID39859367
PMCPMC11765811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.