Evidence map›Paper›PMID 39859353›Full record

Observational studyInternational journal of molecular sciences2025

MicroRNAs in Plasma-Derived Extracellular Vesicles as Non-Invasive Biomarkers for Eosinophilic Esophagitis.

Elena Grueso-Navarro, Leticia Rodríguez-Alcolado, Laura Arias-González, Ana M Aransay, Juan-José Lozano, Julia Sidorova, Rocío Juárez-Tosina, Jesús González-Cervera, Alfredo J Lucendo, Emilio J Laserna-Mendieta

Abstract readObservational Study
In one paragraph

Observational study in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Shifting the scope: Moving toward less invasive diagnosis and monitoring of eosinophilic esophagitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Review
  2. Economic burden of eosinophilic esophagitis in the first year after diagnosis in Spain: A direct medical cost analysis.The European journal of health economics : HEPAC : health economics in prevention and care · 2026
    Observational
  3. Emerging Tissue and Blood Biomarkers for Eosinophilic Esophagitis.Gastroenterology clinics of North America · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elena Grueso-NavarroDepartment of Gastroenterology, Hospital General de Tomelloso, 13700 Tomelloso, Spain.
Leticia Rodríguez-AlcoladoDepartment of Gastroenterology, Hospital General de Tomelloso, 13700 Tomelloso, Spain.ORCID 0009-0004-7394-8967
Laura Arias-GonzálezDepartment of Gastroenterology, Hospital General de Tomelloso, 13700 Tomelloso, Spain.ORCID 0000-0003-2132-9350
Ana M AransayCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0002-8271-612X
Juan-José LozanoCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0001-7613-3908
Julia SidorovaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Rocío Juárez-TosinaDepartment of Pathology, Hospital General La Mancha Centro, 13600 Alcázar de San Juan, Spain.
Jesús González-CerveraInstituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain.ORCID 0000-0002-7444-9076
Alfredo J LucendoDepartment of Gastroenterology, Hospital General de Tomelloso, 13700 Tomelloso, Spain.ORCID 0000-0003-1183-1072
Emilio J Laserna-MendietaDepartment of Gastroenterology, Hospital General de Tomelloso, 13700 Tomelloso, Spain.ORCID 0000-0002-9039-7667

Funding

Instituto de Salud Carlos III (ISCIII, Spain) PI18/01252
6 · The paper itself

Abstract

Eosinophilic esophagitis (EoE) is a chronic inflammatory esophageal disorder. The lack of non-invasive biomarkers currently results in dependency on endoscopy with biopsies for its diagnosis and monitoring. We aimed to identify potential non-invasive biomarkers using microRNAs (miRNAs) in plasma-derived extracellular vesicles (pEVs). This was a prospective single-center observational study of a discovery cohort of EoE patients (

Indexed as

Eosinophilic EsophagitisExtracellular VesiclesMicroRNAsAdultBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedProspective StudiesYoung AdultBiomarkersMicroRNAseosinophilic esophagitis (EoE)extracellular vesicles (EVs)liquid biopsymicroRNAs (miRNAs)non-invasive biomarkerRNA sequencing

Identifiers

PMID39859353
PMCPMC11766357

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.